Rapid decline in episodic memory in healthy older adults with high amyloid-β

Yen Ying Lim, Robert H. Pietrzak, Kathryn A. Ellis, Judith Jaeger, Karra Harrington, Tim Ashwood, Cassandra Szoeke, Ralph N. Martins, Ashley I. Bush, Colin L. Masters, Christopher C. Rowe, Victor L. Villemagne, David Ames, David Darby, Paul Maruff

Research output: Contribution to journalArticleResearchpeer-review

38 Citations (Scopus)


High levels of amyloid-β (Aβ) have been associated with greater rates of decline in episodic memory over 18 months in healthy older adults. Serial assessments over shorter time intervals may facilitate earlier detection of Aβ-related memory decline in healthy older adults. In forty-four healthy older adults enrolled in the Australian Imaging, Biomarkers and Lifestyle Rate of Change Sub-Study, we compared rates of change in cognition over six months in healthy older adults with high and low levels of Aβ. High Aβ was associated with greater decline in episodic memory measures over 6 months in healthy older adults.

Original languageEnglish
Pages (from-to)675-679
Number of pages5
JournalJournal of Alzheimer's Disease
Issue number3
Publication statusPublished - 1 Jan 2013
Externally publishedYes


  • Alzheimer's disease
  • amyloid-β
  • cognitive decline
  • episodic memory
  • neuropsychological assessment

Cite this