Rapid decline in episodic memory in healthy older adults with high amyloid-β

Yen Ying Lim; Robert H. Pietrzak; Kathryn A. Ellis; Judith Jaeger; Karra Harrington; Tim Ashwood; Cassandra Szoeke; Ralph N. Martins; Ashley I. Bush; Colin L. Masters; Christopher C. Rowe; Victor L. Villemagne; David Ames; David Darby; Paul Maruff

doi:10.3233/JAD-2012-121516

Rapid decline in episodic memory in healthy older adults with high amyloid-β

Yen Ying Lim, Robert H. Pietrzak, Kathryn A. Ellis, Judith Jaeger, Karra Harrington, Tim Ashwood, Cassandra Szoeke, Ralph N. Martins, Ashley I. Bush, Colin L. Masters, Christopher C. Rowe, Victor L. Villemagne, David Ames, David Darby, Paul Maruff

Research output: Contribution to journal › Article › Research › peer-review

56 Citations (Scopus)

Abstract

High levels of amyloid-β (Aβ) have been associated with greater rates of decline in episodic memory over 18 months in healthy older adults. Serial assessments over shorter time intervals may facilitate earlier detection of Aβ-related memory decline in healthy older adults. In forty-four healthy older adults enrolled in the Australian Imaging, Biomarkers and Lifestyle Rate of Change Sub-Study, we compared rates of change in cognition over six months in healthy older adults with high and low levels of Aβ. High Aβ was associated with greater decline in episodic memory measures over 6 months in healthy older adults.

Original language	English
Pages (from-to)	675-679
Number of pages	5
Journal	Journal of Alzheimer's Disease
Volume	33
Issue number	3
DOIs	https://doi.org/10.3233/JAD-2012-121516
Publication status	Published - 1 Jan 2013
Externally published	Yes

Keywords

Alzheimer's disease
amyloid-β
cognitive decline
episodic memory
neuropsychological assessment

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.3233/JAD-2012-121516

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Lim, Y. Y., Pietrzak, R. H., Ellis, K. A., Jaeger, J., Harrington, K., Ashwood, T., Szoeke, C., Martins, R. N., Bush, A. I., Masters, C. L., Rowe, C. C., Villemagne, V. L., Ames, D., Darby, D., & Maruff, P. (2013). Rapid decline in episodic memory in healthy older adults with high amyloid-β. Journal of Alzheimer's Disease, 33(3), 675-679. https://doi.org/10.3233/JAD-2012-121516

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abstract = "High levels of amyloid-β (Aβ) have been associated with greater rates of decline in episodic memory over 18 months in healthy older adults. Serial assessments over shorter time intervals may facilitate earlier detection of Aβ-related memory decline in healthy older adults. In forty-four healthy older adults enrolled in the Australian Imaging, Biomarkers and Lifestyle Rate of Change Sub-Study, we compared rates of change in cognition over six months in healthy older adults with high and low levels of Aβ. High Aβ was associated with greater decline in episodic memory measures over 6 months in healthy older adults.",

keywords = "Alzheimer's disease, amyloid-β, cognitive decline, episodic memory, neuropsychological assessment",

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AU - Lim, Yen Ying

AU - Pietrzak, Robert H.

AU - Ellis, Kathryn A.

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AU - Harrington, Karra

AU - Ashwood, Tim

AU - Szoeke, Cassandra

AU - Martins, Ralph N.

AU - Bush, Ashley I.

AU - Masters, Colin L.

AU - Rowe, Christopher C.

AU - Villemagne, Victor L.

AU - Ames, David

AU - Darby, David

AU - Maruff, Paul

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AB - High levels of amyloid-β (Aβ) have been associated with greater rates of decline in episodic memory over 18 months in healthy older adults. Serial assessments over shorter time intervals may facilitate earlier detection of Aβ-related memory decline in healthy older adults. In forty-four healthy older adults enrolled in the Australian Imaging, Biomarkers and Lifestyle Rate of Change Sub-Study, we compared rates of change in cognition over six months in healthy older adults with high and low levels of Aβ. High Aβ was associated with greater decline in episodic memory measures over 6 months in healthy older adults.

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KW - amyloid-β

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KW - neuropsychological assessment

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Rapid decline in episodic memory in healthy older adults with high amyloid-β

Abstract

Keywords

UN SDGs

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