Rapid and specific lowering of pituitary FSHβ mRNA levels by inhibin

I. E. Mercer; J. A. Clements; J. W. Funder; I. J. Clarke

doi:10.1016/0303-7207(87)90181-X

Rapid and specific lowering of pituitary FSHβ mRNA levels by inhibin

I. E. Mercer
, J. A. Clements
, J. W. Funder
, I. J. Clarke

Research output: Contribution to journal › Article › Research › peer-review

71 Citations (Scopus)

Abstract

Hypothalamo-pituitary disconnected sheep were given gonadotrophin releasing hormone pulses every 2 h for 1 week, and the effects of inhibin on mRNA for FSHβ, LHβ, α-subunit and prolactin examined. Levels of FSHβ mRNA were reduced to ~ 20% 6 h after administration, and to ~ 10% by 30 h; no change was seen in LHβ, α-subunit or prolactin mRNA. These data show that inhibin has a very rapid and specific effect on FSHβ mRNA levels directly at the level of the pituitary gland.

Original language	English
Pages (from-to)	251-254
Number of pages	4
Journal	Molecular and Cellular Endocrinology
Volume	53
Issue number	3
DOIs	https://doi.org/10.1016/0303-7207(87)90181-X
Publication status	Published - 1 Jan 1987
Externally published	Yes

Keywords

Follicular fluid
FSH
Inhibin
LH
mRNA
Pituitary
Prolactin

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10.1016/0303-7207(87)90181-X

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title = "Rapid and specific lowering of pituitary FSHβ mRNA levels by inhibin",

abstract = "Hypothalamo-pituitary disconnected sheep were given gonadotrophin releasing hormone pulses every 2 h for 1 week, and the effects of inhibin on mRNA for FSHβ, LHβ, α-subunit and prolactin examined. Levels of FSHβ mRNA were reduced to \textasciitilde{} 20\% 6 h after administration, and to \textasciitilde{} 10\% by 30 h; no change was seen in LHβ, α-subunit or prolactin mRNA. These data show that inhibin has a very rapid and specific effect on FSHβ mRNA levels directly at the level of the pituitary gland.",

keywords = "Follicular fluid, FSH, Inhibin, LH, mRNA, Pituitary, Prolactin",

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year = "1987",

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doi = "10.1016/0303-7207(87)90181-X",

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T1 - Rapid and specific lowering of pituitary FSHβ mRNA levels by inhibin

AU - Mercer, I. E.

AU - Clements, J. A.

AU - Funder, J. W.

AU - Clarke, I. J.

PY - 1987/1/1

Y1 - 1987/1/1

N2 - Hypothalamo-pituitary disconnected sheep were given gonadotrophin releasing hormone pulses every 2 h for 1 week, and the effects of inhibin on mRNA for FSHβ, LHβ, α-subunit and prolactin examined. Levels of FSHβ mRNA were reduced to ~ 20% 6 h after administration, and to ~ 10% by 30 h; no change was seen in LHβ, α-subunit or prolactin mRNA. These data show that inhibin has a very rapid and specific effect on FSHβ mRNA levels directly at the level of the pituitary gland.

AB - Hypothalamo-pituitary disconnected sheep were given gonadotrophin releasing hormone pulses every 2 h for 1 week, and the effects of inhibin on mRNA for FSHβ, LHβ, α-subunit and prolactin examined. Levels of FSHβ mRNA were reduced to ~ 20% 6 h after administration, and to ~ 10% by 30 h; no change was seen in LHβ, α-subunit or prolactin mRNA. These data show that inhibin has a very rapid and specific effect on FSHβ mRNA levels directly at the level of the pituitary gland.

KW - Follicular fluid

KW - FSH

KW - Inhibin

KW - LH

KW - mRNA

KW - Pituitary

KW - Prolactin

UR - https://www.scopus.com/pages/publications/0023196762

U2 - 10.1016/0303-7207(87)90181-X

DO - 10.1016/0303-7207(87)90181-X

M3 - Article

C2 - 3117603

AN - SCOPUS:0023196762

SN - 0303-7207

VL - 53

SP - 251

EP - 254

JO - Molecular and Cellular Endocrinology

JF - Molecular and Cellular Endocrinology

IS - 3

ER -

Rapid and specific lowering of pituitary FSHβ mRNA levels by inhibin

Abstract

Keywords

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