Rapid and safe discharge from the emergency department

A single troponin to exclude acute myocardial infarction

Lisa Brichko, Hans G. Schneider, William Chan, Jarrel Seah, De Villiers Smit, Anthony Dart, Jeremy P. Stevens, Biswadev Mitra

Research output: Contribution to journalArticleResearchpeer-review

1 Citation (Scopus)

Abstract

Objective: To determine variables that could facilitate safe discharge from the ED following a single high-sensitivity troponin I (HsTnI) result to exclude acute myocardial infarction (AMI). Methods: A retrospective cohort study was performed at a tertiary hospital of all patients that had serial HsTnI performed within 12 h of arrival to the ED over a 3 year period. The primary exposure variable of interest was a very low troponin initial result (HsTnI <5 ng/L). Medical record review and risk stratification score calculations were undertaken for all patients with the exposure variable of interest and an abnormal second troponin measurement (HsTnI ≥16 ng/L in women and HsTnI ≥26 ng/L in men). Results: There were 11 970 patients who presented between 1 July 2013 and 30 June 2016 that had serial HsTnI measurements performed. Of these, 4172 (34.9%) patients had an initial HsTnI measurement <5 ng/L. Of the patients with an initial HsTnI <5 ng/L that met inclusion criteria, 56 (1.3%) had a second troponin result above the 99th percentile and 32 (0.8%) cases of non-ST elevation myocardial infarction were diagnosed as well as 15 (0.4%) cases of ST elevation myocardial infarction. There were 44 (93.6%) of all AMI cases that met criteria for high-risk presentations under the National Heart Foundation of Australia guidelines. The negative predictive value of an initial HsTnI <5 ng/L to exclude AMI was 98.9% (95% confidence interval 98.5–99.1). Conclusions: This supports the utilisation of a rapid rule out strategy to exclude AMI for patients that have an initial HsTnI measurement <5 ng/L in conjunction with a robust risk assessment.

Original languageEnglish
Pages (from-to)486-493
Number of pages8
JournalEMA - Emergency Medicine Australasia
Volume30
Issue number4
DOIs
Publication statusPublished - 1 Jan 2018

Keywords

  • Emergency service
  • Hospital
  • Myocardial infarction
  • Non-st elevated myocardial infarction
  • Risk assessment
  • Troponin i

Cite this

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title = "Rapid and safe discharge from the emergency department: A single troponin to exclude acute myocardial infarction",
abstract = "Objective: To determine variables that could facilitate safe discharge from the ED following a single high-sensitivity troponin I (HsTnI) result to exclude acute myocardial infarction (AMI). Methods: A retrospective cohort study was performed at a tertiary hospital of all patients that had serial HsTnI performed within 12 h of arrival to the ED over a 3 year period. The primary exposure variable of interest was a very low troponin initial result (HsTnI <5 ng/L). Medical record review and risk stratification score calculations were undertaken for all patients with the exposure variable of interest and an abnormal second troponin measurement (HsTnI ≥16 ng/L in women and HsTnI ≥26 ng/L in men). Results: There were 11 970 patients who presented between 1 July 2013 and 30 June 2016 that had serial HsTnI measurements performed. Of these, 4172 (34.9{\%}) patients had an initial HsTnI measurement <5 ng/L. Of the patients with an initial HsTnI <5 ng/L that met inclusion criteria, 56 (1.3{\%}) had a second troponin result above the 99th percentile and 32 (0.8{\%}) cases of non-ST elevation myocardial infarction were diagnosed as well as 15 (0.4{\%}) cases of ST elevation myocardial infarction. There were 44 (93.6{\%}) of all AMI cases that met criteria for high-risk presentations under the National Heart Foundation of Australia guidelines. The negative predictive value of an initial HsTnI <5 ng/L to exclude AMI was 98.9{\%} (95{\%} confidence interval 98.5–99.1). Conclusions: This supports the utilisation of a rapid rule out strategy to exclude AMI for patients that have an initial HsTnI measurement <5 ng/L in conjunction with a robust risk assessment.",
keywords = "Emergency service, Hospital, Myocardial infarction, Non-st elevated myocardial infarction, Risk assessment, Troponin i",
author = "Lisa Brichko and Schneider, {Hans G.} and William Chan and Jarrel Seah and Smit, {De Villiers} and Anthony Dart and Stevens, {Jeremy P.} and Biswadev Mitra",
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Rapid and safe discharge from the emergency department : A single troponin to exclude acute myocardial infarction. / Brichko, Lisa; Schneider, Hans G.; Chan, William; Seah, Jarrel; Smit, De Villiers; Dart, Anthony; Stevens, Jeremy P.; Mitra, Biswadev.

In: EMA - Emergency Medicine Australasia, Vol. 30, No. 4, 01.01.2018, p. 486-493.

Research output: Contribution to journalArticleResearchpeer-review

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T1 - Rapid and safe discharge from the emergency department

T2 - A single troponin to exclude acute myocardial infarction

AU - Brichko, Lisa

AU - Schneider, Hans G.

AU - Chan, William

AU - Seah, Jarrel

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AU - Dart, Anthony

AU - Stevens, Jeremy P.

AU - Mitra, Biswadev

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N2 - Objective: To determine variables that could facilitate safe discharge from the ED following a single high-sensitivity troponin I (HsTnI) result to exclude acute myocardial infarction (AMI). Methods: A retrospective cohort study was performed at a tertiary hospital of all patients that had serial HsTnI performed within 12 h of arrival to the ED over a 3 year period. The primary exposure variable of interest was a very low troponin initial result (HsTnI <5 ng/L). Medical record review and risk stratification score calculations were undertaken for all patients with the exposure variable of interest and an abnormal second troponin measurement (HsTnI ≥16 ng/L in women and HsTnI ≥26 ng/L in men). Results: There were 11 970 patients who presented between 1 July 2013 and 30 June 2016 that had serial HsTnI measurements performed. Of these, 4172 (34.9%) patients had an initial HsTnI measurement <5 ng/L. Of the patients with an initial HsTnI <5 ng/L that met inclusion criteria, 56 (1.3%) had a second troponin result above the 99th percentile and 32 (0.8%) cases of non-ST elevation myocardial infarction were diagnosed as well as 15 (0.4%) cases of ST elevation myocardial infarction. There were 44 (93.6%) of all AMI cases that met criteria for high-risk presentations under the National Heart Foundation of Australia guidelines. The negative predictive value of an initial HsTnI <5 ng/L to exclude AMI was 98.9% (95% confidence interval 98.5–99.1). Conclusions: This supports the utilisation of a rapid rule out strategy to exclude AMI for patients that have an initial HsTnI measurement <5 ng/L in conjunction with a robust risk assessment.

AB - Objective: To determine variables that could facilitate safe discharge from the ED following a single high-sensitivity troponin I (HsTnI) result to exclude acute myocardial infarction (AMI). Methods: A retrospective cohort study was performed at a tertiary hospital of all patients that had serial HsTnI performed within 12 h of arrival to the ED over a 3 year period. The primary exposure variable of interest was a very low troponin initial result (HsTnI <5 ng/L). Medical record review and risk stratification score calculations were undertaken for all patients with the exposure variable of interest and an abnormal second troponin measurement (HsTnI ≥16 ng/L in women and HsTnI ≥26 ng/L in men). Results: There were 11 970 patients who presented between 1 July 2013 and 30 June 2016 that had serial HsTnI measurements performed. Of these, 4172 (34.9%) patients had an initial HsTnI measurement <5 ng/L. Of the patients with an initial HsTnI <5 ng/L that met inclusion criteria, 56 (1.3%) had a second troponin result above the 99th percentile and 32 (0.8%) cases of non-ST elevation myocardial infarction were diagnosed as well as 15 (0.4%) cases of ST elevation myocardial infarction. There were 44 (93.6%) of all AMI cases that met criteria for high-risk presentations under the National Heart Foundation of Australia guidelines. The negative predictive value of an initial HsTnI <5 ng/L to exclude AMI was 98.9% (95% confidence interval 98.5–99.1). Conclusions: This supports the utilisation of a rapid rule out strategy to exclude AMI for patients that have an initial HsTnI measurement <5 ng/L in conjunction with a robust risk assessment.

KW - Emergency service

KW - Hospital

KW - Myocardial infarction

KW - Non-st elevated myocardial infarction

KW - Risk assessment

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