Randomized trial: The effect of oral polio vaccine at birth on polio antibody titers at 6 weeks and 6 months of age

Anna Sofie Hansen, Najaaraq Lund, Katie L. Flanagan, Amabelia Rodrigues, Jainaba Njie-jobe, Lady Chilel Sanyang, Ali Salanti, Andreas Andersen, Peter Aaby, Christine Stabell Benn, Hilton Whittle

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3 Citations (Scopus)

Abstract

Background In Guinea-Bissau we conducted a randomized trial of OPV0 versus No OPV0 to test the effect of not receiving OPV0 on infant mortality and morbidity. In two subgroups of participants, 6-week-old children and 6-month-old children, we investigated the effect of OPV0 on neutralizing antibodies against poliovirus type 1 and 3. Design A subgroup of infants randomized to receive OPV0 or No OPV0 in addition to the usual childhood vaccines were visited at home at 6 weeks or 6 months of age, and a blood sample was collected from the child and the mother. Setting Urban Guinea-Bissau. Main outcome Geometric mean titers (GMT) of neutralizing antibodies and seropositivity (titer ≥ 1:8) for poliovirus type 1 and 3. Results OPV0 did not affect the overall seropositivity at 6 weeks or 6 months of age for either polio 1 or 3. In 6-week-old infants, not receiving OPV0 was associated with significantly lower GMT for polio 1 and 3 (GMT ratio = 0.52 (95% CI = 0.33-0.79) for polio 1; 0.44 (0.28-0.70) for polio 3), the effect being significant in its own right in boys and in children whose mothers had low antibody levels. In contrast, in 6-month-old infants, not receiving OPV0 was associated with significantly higher GMT for polio 1 (GMT ratio = 2.10 (1.32-3.35)). This was significant in its own right in boys and in children of mothers with high antibody levels. Conclusions OPV0 may contribute to early polio protection, particularly in children of mothers with low antibody levels. However, OPV0 did not contribute to overall polio immunity after subsequent doses of OPV were given, and was associated with significantly lower antibody titers in children of mothers with high antibody levels. However, it did not negatively affect the proportion of seropositive children.

Original languageEnglish
Pages (from-to)33-39
Number of pages7
JournalTrials in Vaccinology
Volume3
Issue number1
DOIs
Publication statusPublished - 2014
Externally publishedYes

Keywords

  • Antibody
  • Neonates
  • Oral polio vaccine
  • Sex-differences
  • Vaccines

Cite this

Hansen, A. S., Lund, N., Flanagan, K. L., Rodrigues, A., Njie-jobe, J., Sanyang, L. C., Salanti, A., Andersen, A., Aaby, P., Benn, C. S., & Whittle, H. (2014). Randomized trial: The effect of oral polio vaccine at birth on polio antibody titers at 6 weeks and 6 months of age. Trials in Vaccinology, 3(1), 33-39. https://doi.org/10.1016/j.trivac.2014.01.001