Randomized controlled trial to compare sleep and wake in preterm infants less than 32weeks of gestation receiving two different modes of non-invasive respiratory support

C L Collins, C. Barfield, Peter G Davis, R.S.C. Horne

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9 Citations (Scopus)


Aim: To determine whether respiratory support via heated humidified high flow nasal cannulae (HHHFNC) results in infants <. 32. weeks gestation spending a greater proportion of time in sleep compared to those receiving nasal continuous positive airway pressure (NCPAP). Methods: A subgroup of infants enrolled in a randomized controlled trial to compare HHHFNC or NCPAP post-extubation had sleep and wake activity measured by actigraphy for 72. hours post-extubation. Activity diaries were completed contemporaneously to record episodes of infant handling. Actigraphy data were downloaded with known periods of handling excluded from the analysis. Results: 28 infants with mean gestation of 28.3. weeks (SD 2) and birth weight 1074. g (SD 371) were studied. Infants receiving HHHFNC spent a lesser proportion of time in sleep 59.8% (SD 18.5) than those on NCPAP 82.2% (SD 23.8) p = 0.004. Infants receiving HHHFNC had a lower sleep efficiency and higher mean activity score than those on NCPAP (p = 0.003, p. = 0.002, respectively). Conclusion: Infants receiving HHHFNC had a higher mean activity score and spent less time in sleep than those allocated NCPAP. Further study of sleep wake activity in preterm infants receiving respiratory support is required as this may impact on neurodevelopmental outcomes.

Original languageEnglish
Pages (from-to)701-704
Number of pages4
JournalEarly Human Development
Issue number12
Publication statusPublished - Dec 2015


  • High flow nasal cannulae
  • Preterm infant
  • Sleep
  • Wake

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