Randomized controlled trial comparing the effectiveness and safety of intranasal and intramuscular naloxone for the treatment of suspected heroin overdose

Debra Kerr, Anne-Maree Kelly, Paul Mark Dietze, Damien John Jolley, Bill Barger

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    113 Citations (Scopus)


    This study compared the effectiveness of concentrated (2 mg/ml) i.n. naloxone to intramuscular (i.m.) naloxone for suspected opiate overdose. Methods This randomized controlled trial included patients treated for suspected opiate overdose in the pre-hospital setting. Patients received 2 mg of either i.n. or i.m. naloxone. The primary outcome was the proportion of patients who responded within 10 minutes of naloxone treatment. Secondary outcomes included time to adequate response and requirement for supplementary naloxone. Data were analysed usingmultivariate statistical techniques.
    Original languageEnglish
    Pages (from-to)2067 - 2074
    Number of pages8
    Issue number12
    Publication statusPublished - 2009

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