Randomized controlled trial comparing the effectiveness and safety of intranasal and intramuscular naloxone for the treatment of suspected heroin overdose

Debra Kerr, Anne-Maree Kelly, Paul Mark Dietze, Damien John Jolley, Bill Barger

    Research output: Contribution to journal › Article › Research › peer-review

    92 Citations (Scopus)

    Abstract

    This study compared the effectiveness of concentrated (2 mg/ml) i.n. naloxone to intramuscular (i.m.) naloxone for suspected opiate overdose. Methods This randomized controlled trial included patients treated for suspected opiate overdose in the pre-hospital setting. Patients received 2 mg of either i.n. or i.m. naloxone. The primary outcome was the proportion of patients who responded within 10 minutes of naloxone treatment. Secondary outcomes included time to adequate response and requirement for supplementary naloxone. Data were analysed usingmultivariate statistical techniques.
    Original languageEnglish
    Pages (from-to)2067 - 2074
    Number of pages8
    JournalAddiction
    Volume104
    Issue number12
    DOIs
    Publication statusPublished - 2009

    Cite this

    Kerr, Debra ; Kelly, Anne-Maree ; Dietze, Paul Mark ; Jolley, Damien John ; Barger, Bill. / Randomized controlled trial comparing the effectiveness and safety of intranasal and intramuscular naloxone for the treatment of suspected heroin overdose. In: Addiction. 2009 ; Vol. 104, No. 12. pp. 2067 - 2074.
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    abstract = "This study compared the effectiveness of concentrated (2 mg/ml) i.n. naloxone to intramuscular (i.m.) naloxone for suspected opiate overdose. Methods This randomized controlled trial included patients treated for suspected opiate overdose in the pre-hospital setting. Patients received 2 mg of either i.n. or i.m. naloxone. The primary outcome was the proportion of patients who responded within 10 minutes of naloxone treatment. Secondary outcomes included time to adequate response and requirement for supplementary naloxone. Data were analysed usingmultivariate statistical techniques.",
    author = "Debra Kerr and Anne-Maree Kelly and Dietze, {Paul Mark} and Jolley, {Damien John} and Bill Barger",
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    language = "English",
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    Kerr, D, Kelly, A-M, Dietze, PM, Jolley, DJ & Barger, B 2009, 'Randomized controlled trial comparing the effectiveness and safety of intranasal and intramuscular naloxone for the treatment of suspected heroin overdose', Addiction, vol. 104, no. 12, pp. 2067 - 2074. https://doi.org/10.1111/j.1360-0443.2009.02724.x

    Randomized controlled trial comparing the effectiveness and safety of intranasal and intramuscular naloxone for the treatment of suspected heroin overdose. / Kerr, Debra; Kelly, Anne-Maree; Dietze, Paul Mark; Jolley, Damien John; Barger, Bill.

    In: Addiction, Vol. 104, No. 12, 2009, p. 2067 - 2074.

    Research output: Contribution to journal › Article › Research › peer-review

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    AU - Kelly, Anne-Maree

    AU - Dietze, Paul Mark

    AU - Jolley, Damien John

    AU - Barger, Bill

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    Kerr D, Kelly A-M, Dietze PM, Jolley DJ, Barger B. Randomized controlled trial comparing the effectiveness and safety of intranasal and intramuscular naloxone for the treatment of suspected heroin overdose. Addiction. 2009;104(12):2067 - 2074. https://doi.org/10.1111/j.1360-0443.2009.02724.x

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