Randomized controlled trial comparing the effectiveness and safety of intranasal and intramuscular naloxone for the treatment of suspected heroin overdose

Debra Kerr; Anne-Maree Kelly; Paul Mark Dietze; Damien John Jolley; Bill Barger

doi:10.1111/j.1360-0443.2009.02724.x

Randomized controlled trial comparing the effectiveness and safety of intranasal and intramuscular naloxone for the treatment of suspected heroin overdose

Debra Kerr, Anne-Maree Kelly, Paul Mark Dietze, Damien John Jolley, Bill Barger

Research output: Contribution to journal › Article › Research › peer-review

113 Citations (Scopus)

Abstract

This study compared the effectiveness of concentrated (2 mg/ml) i.n. naloxone to intramuscular (i.m.) naloxone for suspected opiate overdose. Methods This randomized controlled trial included patients treated for suspected opiate overdose in the pre-hospital setting. Patients received 2 mg of either i.n. or i.m. naloxone. The primary outcome was the proportion of patients who responded within 10 minutes of naloxone treatment. Secondary outcomes included time to adequate response and requirement for supplementary naloxone. Data were analysed usingmultivariate statistical techniques.

Original language	English
Pages (from-to)	2067 - 2074
Number of pages	8
Journal	Addiction
Volume	104
Issue number	12
DOIs	https://doi.org/10.1111/j.1360-0443.2009.02724.x
Publication status	Published - 2009

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10.1111/j.1360-0443.2009.02724.x

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abstract = "This study compared the effectiveness of concentrated (2 mg/ml) i.n. naloxone to intramuscular (i.m.) naloxone for suspected opiate overdose. Methods This randomized controlled trial included patients treated for suspected opiate overdose in the pre-hospital setting. Patients received 2 mg of either i.n. or i.m. naloxone. The primary outcome was the proportion of patients who responded within 10 minutes of naloxone treatment. Secondary outcomes included time to adequate response and requirement for supplementary naloxone. Data were analysed usingmultivariate statistical techniques.",

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Randomized controlled trial comparing the effectiveness and safety of intranasal and intramuscular naloxone for the treatment of suspected heroin overdose. / Kerr, Debra; Kelly, Anne-Maree; Dietze, Paul Mark; Jolley, Damien John; Barger, Bill.

In: Addiction, Vol. 104, No. 12, 2009, p. 2067 - 2074.

Research output: Contribution to journal › Article › Research › peer-review

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AU - Barger, Bill

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Randomized controlled trial comparing the effectiveness and safety of intranasal and intramuscular naloxone for the treatment of suspected heroin overdose

Abstract

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