RAFT synthesis and DNA binding of biodegradable, hyperbranched poly(2-(dimethylamino)ethyl methacrylate

Lei Tao; Jingquan Liu; Benghoon Tan; Thomas Paul Davis

doi:10.1021/ma900865c

RAFT synthesis and DNA binding of biodegradable, hyperbranched poly(2-(dimethylamino)ethyl methacrylate

Lei Tao, Jingquan Liu, Benghoon Tan, Thomas Paul Davis

Research output: Contribution to journal › Article › Research › peer-review

81 Citations (Scopus)

Abstract

A study was conducted to demonstrate the reversible addition-fragmentation chain transfer (RAFT) synthesis of a biodegradable hyperbranched cationic polymer, poly(2-(dimethylamino)ethyl methacrylate) (PDMAEMA). The RAFT technique was selected to control the polymerization process and obtain low molecular weight branch oligomers with similar chain lengths and low toxicity. A biodegradable disulfide-base dimethacrylate (DSD-MA), 1,2-bis(2-(3-methylbuta-1, 3-dien-2-yloxy)ethyl)disulfane was employed as a cross-link agent to link branched oligomers into hyperbranched structures, with each branch point in the polymer linked by a disulfide bond. Chain transfer agent (CTA), 2-((2-(methacryloyloxy)ethyl)disulfanyl)ethyl 4-cyano-4- (phenylcarbonothioylthio)pentanoate was prepared by the reaction between 2-((2-hydroxyethyl)disulfanyl)ethyl-4-cyano-4-(phenylcarbonothioylthio) pentanoate and methacryloyl chloride in the presence of triethlamine (TEA).

Original language	English
Pages (from-to)	4960 - 4962
Number of pages	3
Journal	Macromolecules
Volume	42
Issue number	14
DOIs	https://doi.org/10.1021/ma900865c
Publication status	Published - 2009
Externally published	Yes

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@article{55bd87f888fd412b8e8788a911519267,

title = "RAFT synthesis and DNA binding of biodegradable, hyperbranched poly(2-(dimethylamino)ethyl methacrylate",

abstract = "A study was conducted to demonstrate the reversible addition-fragmentation chain transfer (RAFT) synthesis of a biodegradable hyperbranched cationic polymer, poly(2-(dimethylamino)ethyl methacrylate) (PDMAEMA). The RAFT technique was selected to control the polymerization process and obtain low molecular weight branch oligomers with similar chain lengths and low toxicity. A biodegradable disulfide-base dimethacrylate (DSD-MA), 1,2-bis(2-(3-methylbuta-1, 3-dien-2-yloxy)ethyl)disulfane was employed as a cross-link agent to link branched oligomers into hyperbranched structures, with each branch point in the polymer linked by a disulfide bond. Chain transfer agent (CTA), 2-((2-(methacryloyloxy)ethyl)disulfanyl)ethyl 4-cyano-4- (phenylcarbonothioylthio)pentanoate was prepared by the reaction between 2-((2-hydroxyethyl)disulfanyl)ethyl-4-cyano-4-(phenylcarbonothioylthio) pentanoate and methacryloyl chloride in the presence of triethlamine (TEA).",

author = "Lei Tao and Jingquan Liu and Benghoon Tan and Davis, {Thomas Paul}",

year = "2009",

doi = "10.1021/ma900865c",

language = "English",

volume = "42",

pages = "4960 -- 4962",

journal = "Macromolecules",

issn = "0024-9297",

publisher = "American Chemical Society",

number = "14",

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TY - JOUR

T1 - RAFT synthesis and DNA binding of biodegradable, hyperbranched poly(2-(dimethylamino)ethyl methacrylate

AU - Tao, Lei

AU - Liu, Jingquan

AU - Tan, Benghoon

AU - Davis, Thomas Paul

PY - 2009

Y1 - 2009

N2 - A study was conducted to demonstrate the reversible addition-fragmentation chain transfer (RAFT) synthesis of a biodegradable hyperbranched cationic polymer, poly(2-(dimethylamino)ethyl methacrylate) (PDMAEMA). The RAFT technique was selected to control the polymerization process and obtain low molecular weight branch oligomers with similar chain lengths and low toxicity. A biodegradable disulfide-base dimethacrylate (DSD-MA), 1,2-bis(2-(3-methylbuta-1, 3-dien-2-yloxy)ethyl)disulfane was employed as a cross-link agent to link branched oligomers into hyperbranched structures, with each branch point in the polymer linked by a disulfide bond. Chain transfer agent (CTA), 2-((2-(methacryloyloxy)ethyl)disulfanyl)ethyl 4-cyano-4- (phenylcarbonothioylthio)pentanoate was prepared by the reaction between 2-((2-hydroxyethyl)disulfanyl)ethyl-4-cyano-4-(phenylcarbonothioylthio) pentanoate and methacryloyl chloride in the presence of triethlamine (TEA).

AB - A study was conducted to demonstrate the reversible addition-fragmentation chain transfer (RAFT) synthesis of a biodegradable hyperbranched cationic polymer, poly(2-(dimethylamino)ethyl methacrylate) (PDMAEMA). The RAFT technique was selected to control the polymerization process and obtain low molecular weight branch oligomers with similar chain lengths and low toxicity. A biodegradable disulfide-base dimethacrylate (DSD-MA), 1,2-bis(2-(3-methylbuta-1, 3-dien-2-yloxy)ethyl)disulfane was employed as a cross-link agent to link branched oligomers into hyperbranched structures, with each branch point in the polymer linked by a disulfide bond. Chain transfer agent (CTA), 2-((2-(methacryloyloxy)ethyl)disulfanyl)ethyl 4-cyano-4- (phenylcarbonothioylthio)pentanoate was prepared by the reaction between 2-((2-hydroxyethyl)disulfanyl)ethyl-4-cyano-4-(phenylcarbonothioylthio) pentanoate and methacryloyl chloride in the presence of triethlamine (TEA).

UR - http://pubs.acs.org/doi/pdfplus/10.1021/ma900865c

U2 - 10.1021/ma900865c

DO - 10.1021/ma900865c

M3 - Article

SN - 0024-9297

VL - 42

SP - 4960

EP - 4962

JO - Macromolecules

JF - Macromolecules

IS - 14

ER -

RAFT synthesis and DNA binding of biodegradable, hyperbranched poly(2-(dimethylamino)ethyl methacrylate

Abstract

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