TY - GEN
T1 - RAFT polymers
T2 - Novel precursors for polymer-protein conjugates
AU - Schilli, Christine M.
AU - Müller, Axel H.E.
AU - Rizzardo, Ezio
AU - Thang, San H.
AU - Chong, Y. K.
PY - 2003/12/1
Y1 - 2003/12/1
N2 - Temperature- and pH-sensitive polymers and block copolymers have been synthesized via reversible addition-fragmentation chain transfer (RAFT) polymerization. Thiocarbonylthio compounds used as chain transfer agents in the polymerization lead to end-functionalized polymers that give the corresponding thiols upon hydrolysis. Both block copolymers with short blocks of oligo(active ester)s and thiol-terminated polymers can be used for polymer-protein conjugation. 2-Vinyl-4,4-dimethyl-5-oxazolone (VO), N-hydroxysuccinimide methacrylate (NHSM), diacetone acrylamide (DAA), N-iso-propylacrylamide (NIPAAm), and acrylic acid (AA) have been polymerized to homo- and block copolymers with narrow MWD in most cases, and their conjugation to model peptides has been investigated. Block copolymers of NIPAAm and AA were investigated for their response to combined external stimuli. Thus, thermo- and pH-responsive systems can be created for control of enzyme activity or molecular recognition processes.
AB - Temperature- and pH-sensitive polymers and block copolymers have been synthesized via reversible addition-fragmentation chain transfer (RAFT) polymerization. Thiocarbonylthio compounds used as chain transfer agents in the polymerization lead to end-functionalized polymers that give the corresponding thiols upon hydrolysis. Both block copolymers with short blocks of oligo(active ester)s and thiol-terminated polymers can be used for polymer-protein conjugation. 2-Vinyl-4,4-dimethyl-5-oxazolone (VO), N-hydroxysuccinimide methacrylate (NHSM), diacetone acrylamide (DAA), N-iso-propylacrylamide (NIPAAm), and acrylic acid (AA) have been polymerized to homo- and block copolymers with narrow MWD in most cases, and their conjugation to model peptides has been investigated. Block copolymers of NIPAAm and AA were investigated for their response to combined external stimuli. Thus, thermo- and pH-responsive systems can be created for control of enzyme activity or molecular recognition processes.
UR - http://www.scopus.com/inward/record.url?scp=49249094496&partnerID=8YFLogxK
M3 - Conference Paper
AN - SCOPUS:49249094496
SN - 9780841238541
T3 - ACS Symposium Series
SP - 603
EP - 618
BT - Advances in Controlled/Living Radical Polymerization
A2 - Matyjaszewski, Krzysztof
ER -