Radiofrequency-triggered release for on-demand delivery of therapeutics from titania nanotube drug-eluting implants

Manpreet Bariana, Moom Sinn Aw, Eli Moore, Nicolas H. Voelcker, Dusan Losic

Research output: Contribution to journalArticleResearchpeer-review

25 Citations (Scopus)

Abstract

Aim: This study aimed to demonstrate radiofrequency (RF)-triggered release of drugs and drug carriers from drug-eluting implants using gold nanoparticles as energy transducers. Materials & methods: Titanium wire with a titania nanotube layer was used as an implant loaded with indomethacin and micelles (tocopheryl PEG succinate) as a drug and drug carrier model. RF signals were generated from a customized RF generator to trigger in vitro release. Results & discussion: Within 2.5 h, 18 mg (92%) of loaded drug and 14 mg (68%) of loaded drug carriers were released using short RF exposure (5 min), compared with 5 mg (31%) of drug and 2 mg (11%) of drug carriers without a RF trigger. Gold nanoparticles can effectively function as RF energy transducers inside titania nanotubes for rapid release of therapeutics at arbitrary times. Conclusion: The results of this study show that RF is a promising strategy for triggered release from implantable drug delivery systems where on-demand delivery of therapeutics is required.

Original languageEnglish
Pages (from-to)1263-1275
Number of pages13
JournalNanomedicine
Volume9
Issue number8
DOIs
Publication statusPublished - 2014
Externally publishedYes

Keywords

  • drug-eluting implant
  • gold nanoparticle
  • micelle
  • noninvasive drug delivery
  • polymer
  • radiofrequency
  • titania nanotube
  • triggered drug release
  • water-insoluble drug

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