Radical scavenging activity of methanol leaf extracts of Orthosiphon stamineus

G. A. Akowuah; I. Zhari; I. Norhayati; A. Sadikun

doi:10.1080/13880200490902572

Radical scavenging activity of methanol leaf extracts of Orthosiphon stamineus

G. A. Akowuah, I. Zhari, I. Norhayati, A. Sadikun

Research output: Contribution to journal › Article › Research › peer-review

23 Citations (Scopus)

Abstract

The antioxidant activity of methanol extracts of Orthosiphon stamineus Benth (Lamiaceae), cultivated in different regions of Malaysia, was determined by measuring the scavenging effect on 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical and on superoxide anion. The results showed a variation in free-radical and superoxide-anion scavenging activities of the methanol extracts ranging from 62.82 to 92.34% and 53.29 to 75.88%, respectively. Methanol extract was active, and its antioxidative potency was comparable to that of pure quercetin and higher than that of the widely used synthetic antioxidant butylated hydroxylanisole (BHA). The UV and HPLC chromatographic fingerprints of the major phenolics were qualitatively similar for all the methanol leaf extracts of Orthosiphon stamineus from various locations.

Original language	English
Pages (from-to)	629-635
Number of pages	7
Journal	Pharmaceutical Biology
Volume	42
Issue number	8
DOIs	https://doi.org/10.1080/13880200490902572
Publication status	Published - Dec 2004
Externally published	Yes

Keywords

Antioxidants
Free-radical scavenging
Orthosiphon stamineus
Superoxide anion

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10.1080/13880200490902572

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@article{c41dc56a18f648b4833a201b2d496959,

title = "Radical scavenging activity of methanol leaf extracts of Orthosiphon stamineus",

abstract = "The antioxidant activity of methanol extracts of Orthosiphon stamineus Benth (Lamiaceae), cultivated in different regions of Malaysia, was determined by measuring the scavenging effect on 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical and on superoxide anion. The results showed a variation in free-radical and superoxide-anion scavenging activities of the methanol extracts ranging from 62.82 to 92.34\% and 53.29 to 75.88\%, respectively. Methanol extract was active, and its antioxidative potency was comparable to that of pure quercetin and higher than that of the widely used synthetic antioxidant butylated hydroxylanisole (BHA). The UV and HPLC chromatographic fingerprints of the major phenolics were qualitatively similar for all the methanol leaf extracts of Orthosiphon stamineus from various locations.",

keywords = "Antioxidants, Free-radical scavenging, Orthosiphon stamineus, Superoxide anion",

author = "Akowuah, \{G. A.\} and I. Zhari and I. Norhayati and A. Sadikun",

note = "Funding Information: The study was supported by Intensifying Research Priority Areas (IRPA) Grant from the Ministry of Science, Technology, and Environment, Malaysia.",

year = "2004",

month = dec,

doi = "10.1080/13880200490902572",

language = "English",

volume = "42",

pages = "629--635",

journal = "Pharmaceutical Biology",

issn = "1388-0209",

publisher = "Taylor \& Francis",

number = "8",

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TY - JOUR

T1 - Radical scavenging activity of methanol leaf extracts of Orthosiphon stamineus

AU - Akowuah, G. A.

AU - Zhari, I.

AU - Norhayati, I.

AU - Sadikun, A.

N1 - Funding Information: The study was supported by Intensifying Research Priority Areas (IRPA) Grant from the Ministry of Science, Technology, and Environment, Malaysia.

PY - 2004/12

Y1 - 2004/12

N2 - The antioxidant activity of methanol extracts of Orthosiphon stamineus Benth (Lamiaceae), cultivated in different regions of Malaysia, was determined by measuring the scavenging effect on 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical and on superoxide anion. The results showed a variation in free-radical and superoxide-anion scavenging activities of the methanol extracts ranging from 62.82 to 92.34% and 53.29 to 75.88%, respectively. Methanol extract was active, and its antioxidative potency was comparable to that of pure quercetin and higher than that of the widely used synthetic antioxidant butylated hydroxylanisole (BHA). The UV and HPLC chromatographic fingerprints of the major phenolics were qualitatively similar for all the methanol leaf extracts of Orthosiphon stamineus from various locations.

AB - The antioxidant activity of methanol extracts of Orthosiphon stamineus Benth (Lamiaceae), cultivated in different regions of Malaysia, was determined by measuring the scavenging effect on 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical and on superoxide anion. The results showed a variation in free-radical and superoxide-anion scavenging activities of the methanol extracts ranging from 62.82 to 92.34% and 53.29 to 75.88%, respectively. Methanol extract was active, and its antioxidative potency was comparable to that of pure quercetin and higher than that of the widely used synthetic antioxidant butylated hydroxylanisole (BHA). The UV and HPLC chromatographic fingerprints of the major phenolics were qualitatively similar for all the methanol leaf extracts of Orthosiphon stamineus from various locations.

KW - Antioxidants

KW - Free-radical scavenging

KW - Orthosiphon stamineus

KW - Superoxide anion

UR - https://www.scopus.com/pages/publications/14944339927

U2 - 10.1080/13880200490902572

DO - 10.1080/13880200490902572

M3 - Article

AN - SCOPUS:14944339927

SN - 1388-0209

VL - 42

SP - 629

EP - 635

JO - Pharmaceutical Biology

JF - Pharmaceutical Biology

IS - 8

ER -

Radical scavenging activity of methanol leaf extracts of Orthosiphon stamineus

Abstract

Keywords

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