Radiation cross-linked carboxymethyl sago pulp hydrogels loaded with ciprofloxacin: Influence of irradiation on gel fraction, entrapped drug and in vitro release

Yi Lyn Lam, Saravanan Muniyandy, Kamaruddin Hashim, Ahmad Mansor, Pushpamalar Janarthanan

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    Abstract

    Carboxymethyl sago pulp(CMSP)with 0.4DS, viscosity 184dl/g and molecular weight 76,000g/mol was synthesized from sago waste.10 and 20 w/v solutions of CMSP were irradiated at 10?30 kGy to form hydrogels and were characterized by gel fraction(GF). Irradiation of 20 CMSP using 25kGy has produced stable hydrogels with the highest GF and hence loaded with ciprofloxacin HCl.Drug-loaded hydrogels were produced by irradiating the mixture of drug and 20 CMSP solution at 25kGy. After irradiation, the hydrogels were cut into circular discs with a diameter of 671 mm and evaluated for physico chemical properties as well as drug release kinetics. The ciprofloxacin loading in the disc was 14.7 71 w/w with an entrapment efficiency of 73.5 w/w. The low standard deviation of drug-loaded discs indicated uniform thickness (1.570.3 mm). The unloaded discs were thinner (170.4 mm)and more brittle than the drug-loaded discs. FESEM,FT-IR, XRD, DSC and TGA analysis revealed the absence of polymer?drug interaction and transformation of crystalline to amorphous form of ciprofloxacin in the discs. The disc sustained the drug release in phosphate buffer pH 7.4 over 36 h in a first-order manner. The mechanism of the drug release was found to be swelling controlled diffusion and matrix erosion. The anti-bacterial effect of ciprofloxacin was retained after irradiation and CMSP disc could be a promising device for ocular drug delivery.
    Original languageEnglish
    Pages (from-to)213 - 222
    Number of pages10
    JournalRadiation Physics and Chemistry: the journal for radiation physics, radiation chemistry and radiation processing
    Volume106
    DOIs
    Publication statusPublished - 2015

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