Quorum sensing inhibitory activity of giganteone a from Myristica Cinnamomea king against Escherichia coli biosensors

Yasodha Sivasothy, Thiba Krishnan, Kok Gan Chan, Siti Mariam Abdul Wahab, Muhamad Aqmal Othman, Marc Litaudon, Khalijah Awang

Research output: Contribution to journalArticleResearchpeer-review

8 Citations (Scopus)


Malabaricones A-C (1-3) and giganteone A (4) were isolated from the bark of Myristica cinnamomea King. Their structures were elucidated and characterized by means of NMR and MS spectral analyses. These isolates were evaluated for their anti-quorum sensing activity using quorum sensing biosensors, namely Escherichia coli [pSB401] and Escherichia coli [pSB1075], whereby the potential of giganteone A (4) as a suitable anti-quorum sensing agent was demonstrated.

Original languageEnglish
Article number391
Number of pages7
Issue number3
Publication statusPublished - Mar 2016
Externally publishedYes


  • Acylphenols
  • Anti-quorum sensing activity
  • Dimeric acylphenols
  • Myristica cinnamomea King
  • Myristicaceae

Cite this