Quantitative x-ray phase-contrast imaging using a single grating of comparable pitch to sample feature size

Kaye Morgan, David Paganin, Karen Siu

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    33 Citations (Scopus)


    The ability to quantitatively retrieve transverse phase maps during imaging by using coherent x rays often requires a precise grating or analyzer-crystal-based setup. Imaging of live animals presents further challenges when these methods require multiple exposures for image reconstruction. We present a simple method of single-exposure, single- grating quantitative phase contrast for a regime in which the grating period is much greater than the effective pixel size. A grating is used to create a high-visibility reference pattern incident on the sample, which is distorted according to the complex refractive index and thickness of the sample. The resolution, along a line parallel to the grating, is not restricted by the grating spacing, and the detector resolution becomes the primary determinant of the spatial resolution. We present a method of analysis that maps the displacement of interrogation windows in order to retrieve a quantitative phase map. Application of this analysis to the imaging of known phantoms shows excellent correspondence
    Original languageEnglish
    Pages (from-to)55 - 57
    Number of pages3
    JournalOptics Letters
    Issue number1
    Publication statusPublished - 2011

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