Quantitative conformational analyses predict distinct receptor sites for PCP-like and σ drugs

David T. Manallack, Philip M. Beart

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26 Citations (Scopus)

Abstract

Computer-assisted molecular modelling techniques have been employed to develop receptor models for the phencyclidine (PCP) and σ binding sites. The models differ in the position of the nitrogen atom, direction of the nitrogen-lone pair vector and in the location and nature of secondary binding groups. This study predicts the existence of distinct receptors for σ and PCP ligands, and our receptor models can be used to design and predict the activity of drugs with PCP and/or σ activity.

Original languageEnglish
Pages (from-to)231-235
Number of pages5
JournalEuropean Journal of Pharmacology
Volume144
Issue number2
DOIs
Publication statusPublished - 1 Dec 1987
Externally publishedYes

Keywords

  • (+) [H]SKF 10,047
  • (Molecular conformation, Computer graphics)
  • N-Methyl-D-aspartate
  • Phencyclidine receptor
  • [H]1-[1-(2-Thienyl)cyclohexyl]piperidine
  • σ Receptors

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