Quantitative Assessment of Cerebellar Ataxia with Kinematic Sensing during Rhythmic Tapping

Khoa D. Nguyen, Pubudu N. Pathirana, Malcolm Horne, Laura Power, David Szmulewicz

Research output: Chapter in Book/Report/Conference proceedingConference PaperResearchpeer-review

8 Citations (Scopus)

Abstract

The aim of this study is to investigate the validity of an entropy-based objective assessment of cerebellar ataxia patients performing rhythmic tapping. Previous research conducted, particularly in time and frequency domains, tested the adherence of patients to more stringent experimental requirements. These requirements may inadvertently cause higher level brain functions to influence the performance and possibly obscure the cerebella related disabilities in the data stream. In this study, a multiscale entropy-based learning process that overcomes this practical limitation was considered. In particular, assessment techniques with less restrictions on the tapping duration were considered. Thirty-three patients were engaged in the test, with three levels of severity 0 (normal), 1 (moderate) and 2 (severe) ranked by specialist clinicians. The performance of each model was evaluated using leave-oneout cross validation. Results from both time-frequency features and entropy features extracted and characterized the cerebellar condition captured during the finger and foot tapping tests (with over 80% accuracy). Strong correlations with clinical assessment-based scoring were observed with the entropy based approach for both tests, although the correlation with timefrequency features were less convincing.

Original languageEnglish
Title of host publication40th Annual International Conference of the IEEE Engineering in Medicine and Biology Society
EditorsGregg Suaning, Olaf Dossel
Place of PublicationDanvers MA USA
PublisherIEEE, Institute of Electrical and Electronics Engineers
Pages1098-1101
Number of pages4
ISBN (Electronic)9781538636466, 9781538636459
DOIs
Publication statusPublished - 26 Oct 2018
Externally publishedYes
EventInternational Conference of the IEEE Engineering in Medicine and Biology Society 2018 - Honolulu, United States of America
Duration: 17 Jul 201821 Jul 2018
Conference number: 40th
https://embc.embs.org/2018/
https://ieeexplore.ieee.org/xpl/conhome/8471725/proceeding (Proceedings)

Conference

ConferenceInternational Conference of the IEEE Engineering in Medicine and Biology Society 2018
Abbreviated titleEMBC 2018
Country/TerritoryUnited States of America
CityHonolulu
Period17/07/1821/07/18
Internet address

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