Quantitative accuracy of delayed hyperperfusion in MRI of transient ischemia in rats

Kazuhiro Nakamura, David Wright, Yasushi Kondoh, Shigenori Mizusawa, Toshibumi Kinoshita

Research output: Chapter in Book/Report/Conference proceedingConference PaperResearchpeer-review

5 Citations (Scopus)


A strong hyperperfusion was reported in transient ischemic tissue between 48 and 72 hours after middle cerebral artery occlusion (MCAO). Cerebral blood flow (CBF) estimated by continuous arterial spin labeling (CASL) with short delay after tagging was sensitive to cerebral blood volume (CBV) change. The delayed hyperperfusion may indicate a CBV increase after MCAO. For confirmation of the delayed hyperperfusion, we investigated a transit-time dependency in CASL at two days after MCAO. We also acquired CBF using the dynamic susceptibility contrast (DSC) at the same day. We have confirmed the CBF in transient ischemic tissue is quite higher (179.1± 21.6 ml/lOOg/min) than normal tissue (121.0± 6.9 ml/lOOg/min) with CASL using tagging delay of 0.4 sec. CBF estimated by DSC also show delayed hyperperfusion in transient ischemic tissue. These results confirm existence of physiological delayed hyperperfusion in transient ischemic area.

Original languageEnglish
Title of host publicationProceedings of the 30th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS'08
PublisherIEEE, Institute of Electrical and Electronics Engineers
Number of pages4
ISBN (Print)9781424418152
Publication statusPublished - 2008
Externally publishedYes
EventInternational Conference of the IEEE Engineering in Medicine and Biology Society 2008 - Vancouver Convention and Exhibition Centre, Vancouver, Canada
Duration: 20 Aug 200825 Aug 2008
Conference number: 30th
https://ieeexplore.ieee.org/xpl/conhome/4636107/proceeding (Proceedings)


ConferenceInternational Conference of the IEEE Engineering in Medicine and Biology Society 2008
Abbreviated titleEMBC 2008
Internet address

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