Quantitation of suspected allergens in fragrances (Part I): Evaluation of comprehensive two-dimensional gas chromatography for quality control

Robert Shellie, Philip Marriott, Alain Chaintreau

Research output: Contribution to journalArticleResearchpeer-review

57 Citations (Scopus)


An evaluation of comprehensive two-dimensional (2D) gas chromatography (GC×GC) was performed to assess its suitability for the analysis of volatile fragrance components, recognized by the European Commission's Scientific Committee on Cosmetics and other Non-food Products (SCCNFP) as possible skin sensitizers. The 24 volatile components listed by the SCCNFP were baseline-resolved or better within one 30 min analysis. High-quality calibration data for standard mixtures were obtained, with R2 > 0.998 over the concentration range 2-1000 mg/l. However, the analysis of small spiked amounts of target compounds in truly complex fragrances was problematic, due to uncertainty in component assignment. The benefits and limitations of GC×GC are reported, and a discussion of the proposed directions for the solution of this analysis is provided.

Original languageEnglish
Pages (from-to)91-98
Number of pages8
JournalFlavour and Fragrance Journal
Issue number2
Publication statusPublished - 1 Mar 2004
Externally publishedYes


  • Allergens
  • Fragrances
  • GCxGC
  • Multidimensional GC
  • Quality control

Cite this