Quantifying Uncertainty in the Ratio of Two Measured Variables: A Recap and Example

David M. Shackleford, Kris M. Jamsen

Research output: Contribution to journalArticleOtherpeer-review

4 Citations (Scopus)

Abstract

Estimating uncertainty in the ratio of 2 measured variables can be achieved via 2 seemingly different approaches: by determining the variance of the first-order Taylor approximation to the ratio, or by the so-called “Propagation of Error” approach. This Lesson Learned shows that the 2 approaches are mathematically equivalent, and provides an example of the approach.

Original languageEnglish
Pages (from-to)3462-3463
Number of pages2
JournalJournal of Pharmaceutical Sciences
Volume105
Issue number11
DOIs
Publication statusPublished - 1 Nov 2016

Keywords

  • ADME
  • bioavailability
  • caco-2 cells
  • in vitro models
  • pharmacokinetics

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