Quantifying podocyte depletion: theoretical and practical considerations

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Abstract

Podocyte depletion is a central event in the pathogenesis of many glomerular diseases. For this reason, methods to quantify podocyte depletion have become increasingly important. Here, we review currently available methods for quantifying podocyte depletion, including the analysis of glomerular cross-sections, the most important and common stereological methods and newer techniques such as whole glomerular analysis in optically cleared samples. Each method has advantages and limitations. We therefore discuss theoretical and practical considerations to assist the selection of the most appropriate method for an individual study.

Original languageEnglish
Pages (from-to)229-236
Number of pages8
JournalCell and Tissue Research
Volume369
Issue number1
DOIs
Publication statusPublished - 1 Jul 2017

Keywords

  • Glomerulus
  • Kidney disease
  • Microscopy
  • Morphometry
  • Podocyte

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