Projects per year
Abstract
Podocyte depletion is a central event in the pathogenesis of many glomerular diseases. For this reason, methods to quantify podocyte depletion have become increasingly important. Here, we review currently available methods for quantifying podocyte depletion, including the analysis of glomerular cross-sections, the most important and common stereological methods and newer techniques such as whole glomerular analysis in optically cleared samples. Each method has advantages and limitations. We therefore discuss theoretical and practical considerations to assist the selection of the most appropriate method for an individual study.
| Original language | English |
|---|---|
| Pages (from-to) | 229-236 |
| Number of pages | 8 |
| Journal | Cell and Tissue Research |
| Volume | 369 |
| Issue number | 1 |
| DOIs | |
| Publication status | Published - 1 Jul 2017 |
Keywords
- Glomerulus
- Kidney disease
- Microscopy
- Morphometry
- Podocyte
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Defining the central role of podocyte depletion in the development, progression and management of glomerular disease
Bertram, J. (Primary Chief Investigator (PCI)), Nikolic-Paterson, D. (Chief Investigator (CI)) & Denton, K. (Chief Investigator (CI))
National Health and Medical Research Council (NHMRC) (Australia)
1/01/17 → 31/12/19
Project: Research
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Birth weight, adult weight and podocyte depletion.
Bertram, J. (Primary Chief Investigator (PCI)), Armitage, J. (Chief Investigator (CI)), Black, M. (Chief Investigator (CI)) & Hoy, W. E. (Chief Investigator (CI))
National Health and Medical Research Council (NHMRC) (Australia)
1/01/14 → 31/12/17
Project: Research
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Novel signalling pathways leading to the activation of glomerular parietal epithelial cells
Puelles Rodriguez, V. (Primary Chief Investigator (PCI))
1/01/17 → 1/03/20
Project: Research