Quality of life and mood in children with cystic fibrosis: Associations with sleep quality

Moya Vandeleur, Lisa M. Walter, David S. Armstrong, Philip Robinson, Gillian M. Nixon, Rosemary S.C. Horne

Research output: Contribution to journalArticleResearchpeer-review

Abstract

Background: We aimed to investigate the relationship between sleep quality, mood and health-related quality of life (HRQOL) in children with CF and controls. Methods: Children (7-12. years) and adolescents (13-18. years) with CF and controls completed sleep evaluation: overnight oximetry and 14. days of actigraphy. Age-appropriate questionnaires assessed mood (Children's Depression Inventory; CDI or Beck's Depression Inventory), HRQOL (CF Questionnaire-Revised; CFQ-R or PedsQL), and sleepiness (Pediatric Daytime Sleepiness Scale). Results: 87 CF and 55 controls recruited. Children with CF had poorer sleep quality, more sleepiness and lower mood than controls, with a negative correlation between mood score and sleep efficiency. Sleepiness score was predictive of mood score and multiple CFQ-R domains. Adolescents with CF also demonstrated poorer sleep and more sleepiness than controls, but no difference in mood. Reduced sleep quality predicted lower CFQ-R scores. No correlation between sleep, mood or HRQOL in controls. Conclusions: In children and adolescents with CF, impaired sleep quality is associated with lower mood and HRQOL in an age-specific manner. Future research will aid understanding of effective strategies for prevention and treatment of mood disorders and sleep disturbance in children with CF.

Original languageEnglish
Pages (from-to)811-820
Number of pages10
JournalJournal of Cystic Fibrosis
Volume17
Issue number6
DOIs
Publication statusPublished - Nov 2018

Keywords

  • Children
  • Mood
  • Quality of life
  • Sleep

Cite this

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title = "Quality of life and mood in children with cystic fibrosis: Associations with sleep quality",
abstract = "Background: We aimed to investigate the relationship between sleep quality, mood and health-related quality of life (HRQOL) in children with CF and controls. Methods: Children (7-12. years) and adolescents (13-18. years) with CF and controls completed sleep evaluation: overnight oximetry and 14. days of actigraphy. Age-appropriate questionnaires assessed mood (Children's Depression Inventory; CDI or Beck's Depression Inventory), HRQOL (CF Questionnaire-Revised; CFQ-R or PedsQL), and sleepiness (Pediatric Daytime Sleepiness Scale). Results: 87 CF and 55 controls recruited. Children with CF had poorer sleep quality, more sleepiness and lower mood than controls, with a negative correlation between mood score and sleep efficiency. Sleepiness score was predictive of mood score and multiple CFQ-R domains. Adolescents with CF also demonstrated poorer sleep and more sleepiness than controls, but no difference in mood. Reduced sleep quality predicted lower CFQ-R scores. No correlation between sleep, mood or HRQOL in controls. Conclusions: In children and adolescents with CF, impaired sleep quality is associated with lower mood and HRQOL in an age-specific manner. Future research will aid understanding of effective strategies for prevention and treatment of mood disorders and sleep disturbance in children with CF.",
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Quality of life and mood in children with cystic fibrosis : Associations with sleep quality. / Vandeleur, Moya; Walter, Lisa M.; Armstrong, David S.; Robinson, Philip; Nixon, Gillian M.; Horne, Rosemary S.C.

In: Journal of Cystic Fibrosis, Vol. 17, No. 6, 11.2018, p. 811-820.

Research output: Contribution to journalArticleResearchpeer-review

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T1 - Quality of life and mood in children with cystic fibrosis

T2 - Associations with sleep quality

AU - Vandeleur, Moya

AU - Walter, Lisa M.

AU - Armstrong, David S.

AU - Robinson, Philip

AU - Nixon, Gillian M.

AU - Horne, Rosemary S.C.

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AB - Background: We aimed to investigate the relationship between sleep quality, mood and health-related quality of life (HRQOL) in children with CF and controls. Methods: Children (7-12. years) and adolescents (13-18. years) with CF and controls completed sleep evaluation: overnight oximetry and 14. days of actigraphy. Age-appropriate questionnaires assessed mood (Children's Depression Inventory; CDI or Beck's Depression Inventory), HRQOL (CF Questionnaire-Revised; CFQ-R or PedsQL), and sleepiness (Pediatric Daytime Sleepiness Scale). Results: 87 CF and 55 controls recruited. Children with CF had poorer sleep quality, more sleepiness and lower mood than controls, with a negative correlation between mood score and sleep efficiency. Sleepiness score was predictive of mood score and multiple CFQ-R domains. Adolescents with CF also demonstrated poorer sleep and more sleepiness than controls, but no difference in mood. Reduced sleep quality predicted lower CFQ-R scores. No correlation between sleep, mood or HRQOL in controls. Conclusions: In children and adolescents with CF, impaired sleep quality is associated with lower mood and HRQOL in an age-specific manner. Future research will aid understanding of effective strategies for prevention and treatment of mood disorders and sleep disturbance in children with CF.

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