Quality of life after intestinal resection in patients with Crohn Disease: A systematic review

Francis J. Ha, Louisa Thong, Hanan Khalil

Research output: Contribution to journalReview ArticleResearchpeer-review

8 Citations (Scopus)


Background/Aims: Most patients with Crohn disease (CD) require surgery within 10 years of diagnosis. Intestinal resection is the most commonly performed operation although the effects on health-related quality of life (HRQOL), particularly long-term, are contentious. Methods: We conducted a systematic review evaluating the impact of intestinal resection on the HRQOL of CD patients, predictors of postoperative HRQOL, and patient satisfaction with surgery. Results: Nine studies including 1,108 CD patients undergoing intestinal resection were identified as eligible for inclusion. The median age at surgery was 29-41 years with varying follow-up period (range 30 days-5 years). Ileocolic resection was the most commonly performed operation on an elective basis (range 95-100%). HRQOL improved as early as 2 weeks postoperatively and lasted up to 5 years across both generic and gastrointestinal domains. Gender, smoking, and disease recurrence were potential predictors of postoperative HRQOL. Patient satisfaction is high with regard to surgery, with preference for a laparoscopic approach. Conclusion: Intestinal resection in CD patients improved HRQOL in the short- and long-term and patients describe high satisfaction about their surgery. Further studies are needed to validate potential predictors of postoperative HRQOL in this cohort.

Original languageEnglish
Pages (from-to)355-363
Number of pages9
JournalDigestive Surgery
Issue number5
Publication statusPublished - Aug 2017


  • Crohn disease
  • Intestinal resection
  • Quality of life
  • Surgery

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