Quality of life after cytoreductive surgery and hyperthermic intraperitoneal chemotherapy for peritoneal carcinomatosis: A systematic review and meta-analysis

Leonard Shan, Akshat Saxena, Bernard L Shan, David L Morris

Research output: Contribution to journalArticleOther

26 Citations (Scopus)


Objective: To review the effect of cytoreductive surgery (CRS) and hyperthermic intra-peritoneal chemotherapy (HIPEC) on health-related quality of life (HRQOL) in patients with peritoneal carcinomatosis. Background: CRS and HIPEC is increasingly performed with curative intent for peritoneal carcinomatosis. Significant morbidity rates are reported in the context of limited life-expectancy, necessitating accurate post-operative HRQOL outcome data. . Methods: A systematic review of clinical studies published after January 2000 was performed using strict eligibility criteria. Key outcomes measures were post-operative HRQOL compared to pre-operative levels and reference populations. Quality appraisal and data tabulation were performed using pre-determined forms. Data were synthesised by narrative review and random-effects meta-analysis. Tau2 and I2 values and Funnel plots were analysed for consistency and bias.
Original languageEnglish
Pages (from-to)199 - 210
Number of pages12
JournalSurgical Oncology
Issue number4
Publication statusPublished - 2014

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