Qualitative support for the gradient model of cardiac pacemaker heterogeneity

Shaun L. Cloherty; Socrates Dokos; Nigel H. Lovell

doi:10.1109/IEMBS.2005.1616360

Qualitative support for the gradient model of cardiac pacemaker heterogeneity

Shaun L. Cloherty, Socrates Dokos, Nigel H. Lovell

Research output: Chapter in Book/Report/Conference proceeding › Conference Paper › Research › peer-review

4 Citations (Scopus)

Abstract

In this study, we investigate the role of sinoatrial node (SAN) cellular heterogeneity in normal cardiac pacemaker function. Using detailed ionic models of electrical activity in SAN and atrial myocytes, we have formulated a number of models of SAN heterogeneity based on discrete-region (in which central and peripheral SAN type cell are separated into discrete regions), gradient and mosaic models of SAN organisation. Simulations of each of the different models were performed in one and two dimensions in the presence of both uniform and linearly increasing conductivity profiles. Simulation results suggest that the gradient model, in which cells display a smooth variation in membrane properties from the center to the periphery of the SAN, best reproduces action potential waveshapes and a site of earliest activation consistent with experimental observations in the intact SAN. We therefore propose that the gradient model of SAN heterogeneity represents the most plausible model of SAN organisation.

Original language	English
Title of host publication	2005 27th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, Vols 1-7
Pages	133-136
Number of pages	4
DOIs	https://doi.org/10.1109/IEMBS.2005.1616360
Publication status	Published - 2005
Externally published	Yes
Event	International Conference of the IEEE Engineering in Medicine and Biology Society 2005 - Shanghai, China Duration: 1 Sept 2005 → 4 Sept 2005 Conference number: 27th https://ieeexplore.ieee.org/xpl/conhome/10755/proceeding (Proceedings)

Conference

Conference	International Conference of the IEEE Engineering in Medicine and Biology Society 2005
Abbreviated title	EMBC 2005
Country/Territory	China
City	Shanghai
Period	1/09/05 → 4/09/05
Internet address	https://ieeexplore.ieee.org/xpl/conhome/10755/proceeding (Proceedings)

Access to Document

10.1109/IEMBS.2005.1616360

Cite this

@inproceedings{b8a53cd506b148fb9ed7023cf0194165,

title = "Qualitative support for the gradient model of cardiac pacemaker heterogeneity",

abstract = "In this study, we investigate the role of sinoatrial node (SAN) cellular heterogeneity in normal cardiac pacemaker function. Using detailed ionic models of electrical activity in SAN and atrial myocytes, we have formulated a number of models of SAN heterogeneity based on discrete-region (in which central and peripheral SAN type cell are separated into discrete regions), gradient and mosaic models of SAN organisation. Simulations of each of the different models were performed in one and two dimensions in the presence of both uniform and linearly increasing conductivity profiles. Simulation results suggest that the gradient model, in which cells display a smooth variation in membrane properties from the center to the periphery of the SAN, best reproduces action potential waveshapes and a site of earliest activation consistent with experimental observations in the intact SAN. We therefore propose that the gradient model of SAN heterogeneity represents the most plausible model of SAN organisation.",

author = "Cloherty, {Shaun L.} and Socrates Dokos and Lovell, {Nigel H.}",

note = "27th Annual International Conference of the IEEE-Engineering-in-Medicine-and-Biology-Society, Shanghai, PEOPLES R CHINA, AUG 31-SEP 03, 2005; International Conference of the IEEE Engineering in Medicine and Biology Society 2005, EMBC 2005 ; Conference date: 01-09-2005 Through 04-09-2005",

year = "2005",

doi = "10.1109/IEMBS.2005.1616360",

language = "English",

isbn = "0780387406",

pages = "133--136",

booktitle = "2005 27th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, Vols 1-7",

url = "https://ieeexplore.ieee.org/xpl/conhome/10755/proceeding",

}

Cloherty, SL, Dokos, S & Lovell, NH 2005, Qualitative support for the gradient model of cardiac pacemaker heterogeneity. in 2005 27th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, Vols 1-7. pp. 133-136, International Conference of the IEEE Engineering in Medicine and Biology Society 2005, Shanghai, China, 1/09/05. https://doi.org/10.1109/IEMBS.2005.1616360

Qualitative support for the gradient model of cardiac pacemaker heterogeneity. / Cloherty, Shaun L.; Dokos, Socrates; Lovell, Nigel H.
2005 27th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, Vols 1-7. 2005. p. 133-136.

Research output: Chapter in Book/Report/Conference proceeding › Conference Paper › Research › peer-review

TY - GEN

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AU - Dokos, Socrates

AU - Lovell, Nigel H.

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AB - In this study, we investigate the role of sinoatrial node (SAN) cellular heterogeneity in normal cardiac pacemaker function. Using detailed ionic models of electrical activity in SAN and atrial myocytes, we have formulated a number of models of SAN heterogeneity based on discrete-region (in which central and peripheral SAN type cell are separated into discrete regions), gradient and mosaic models of SAN organisation. Simulations of each of the different models were performed in one and two dimensions in the presence of both uniform and linearly increasing conductivity profiles. Simulation results suggest that the gradient model, in which cells display a smooth variation in membrane properties from the center to the periphery of the SAN, best reproduces action potential waveshapes and a site of earliest activation consistent with experimental observations in the intact SAN. We therefore propose that the gradient model of SAN heterogeneity represents the most plausible model of SAN organisation.

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