QSAR studies of hydrazone uncouplers of oxidative phosphorylation

D. A. Winkler; G. Holan; D. R J Smith; E. J. Middleton; N. K. Hart; K. Rihs; K. W. Smith

QSAR studies of hydrazone uncouplers of oxidative phosphorylation

D. A. Winkler, G. Holan, D. R J Smith, E. J. Middleton, N. K. Hart, K. Rihs, K. W. Smith

Research output: Contribution to journal › Article › Other

Abstract

Semiempirical molecular orbital calculations have been performed on a series of hydrazone uncouplers of mitochondrial oxidative phosphorylation which show insecticidal activity. Regression analysis yielded significant correlations between uncoupling activity, insecticidal potency and such physicochemical or theoretically-derived parameters as lipophilicity, pK(a) and atom charges.

Original language	English
Pages (from-to)	191-207
Number of pages	17
Journal	Drug Design and Delivery
Volume	3
Issue number	2 SPEC. ISS.
Publication status	Published - 1988
Externally published	Yes

Cite this

@article{e313c3470e964b0fbb4752f820fc7908,

title = "QSAR studies of hydrazone uncouplers of oxidative phosphorylation",

abstract = "Semiempirical molecular orbital calculations have been performed on a series of hydrazone uncouplers of mitochondrial oxidative phosphorylation which show insecticidal activity. Regression analysis yielded significant correlations between uncoupling activity, insecticidal potency and such physicochemical or theoretically-derived parameters as lipophilicity, pK(a) and atom charges.",

author = "Winkler, \{D. A.\} and G. Holan and Smith, \{D. R J\} and Middleton, \{E. J.\} and Hart, \{N. K.\} and K. Rihs and Smith, \{K. W.\}",

year = "1988",

language = "English",

volume = "3",

pages = "191--207",

journal = "Drug Design and Delivery",

issn = "0884-2884",

publisher = "Taylor \& Francis",

number = "2 SPEC. ISS.",

}

TY - JOUR

T1 - QSAR studies of hydrazone uncouplers of oxidative phosphorylation

AU - Winkler, D. A.

AU - Holan, G.

AU - Smith, D. R J

AU - Middleton, E. J.

AU - Hart, N. K.

AU - Rihs, K.

AU - Smith, K. W.

PY - 1988

Y1 - 1988

N2 - Semiempirical molecular orbital calculations have been performed on a series of hydrazone uncouplers of mitochondrial oxidative phosphorylation which show insecticidal activity. Regression analysis yielded significant correlations between uncoupling activity, insecticidal potency and such physicochemical or theoretically-derived parameters as lipophilicity, pK(a) and atom charges.

AB - Semiempirical molecular orbital calculations have been performed on a series of hydrazone uncouplers of mitochondrial oxidative phosphorylation which show insecticidal activity. Regression analysis yielded significant correlations between uncoupling activity, insecticidal potency and such physicochemical or theoretically-derived parameters as lipophilicity, pK(a) and atom charges.

UR - https://www.scopus.com/pages/publications/0023755638

M3 - Article

C2 - 3255329

SN - 0884-2884

VL - 3

SP - 191

EP - 207

JO - Drug Design and Delivery

JF - Drug Design and Delivery

IS - 2 SPEC. ISS.

ER -

QSAR studies of hydrazone uncouplers of oxidative phosphorylation

Abstract

Other files and links

Cite this