QSAR studies of hydrazone uncouplers of oxidative phosphorylation

D. A. Winkler, G. Holan, D. R J Smith, E. J. Middleton, N. K. Hart, K. Rihs, K. W. Smith

Research output: Contribution to journalArticleOther

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Abstract

Semiempirical molecular orbital calculations have been performed on a series of hydrazone uncouplers of mitochondrial oxidative phosphorylation which show insecticidal activity. Regression analysis yielded significant correlations between uncoupling activity, insecticidal potency and such physicochemical or theoretically-derived parameters as lipophilicity, pK(a) and atom charges.

Original languageEnglish
Pages (from-to)191-207
Number of pages17
JournalDrug Design and Delivery
Volume3
Issue number2 SPEC. ISS.
Publication statusPublished - 1988
Externally publishedYes

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