Semiempirical molecular orbital calculations have been performed on a series of hydrazone uncouplers of mitochondrial oxidative phosphorylation which show insecticidal activity. Regression analysis yielded significant correlations between uncoupling activity, insecticidal potency and such physicochemical or theoretically-derived parameters as lipophilicity, pK(a) and atom charges.
|Number of pages||17|
|Journal||Drug Design and Delivery|
|Issue number||2 SPEC. ISS.|
|Publication status||Published - 1988|