Pyrrolidinones derived from (S)-pyroglutamic acid. Part 4. α, β-Diaminopyrrolidinones

Philip W.H. Chan, Ian F. Cottrell, Mark G. Moloney

Research output: Contribution to journalArticleResearchpeer-review

17 Citations (Scopus)

Abstract

The electrophilic amination of a Ε γ-aminolactam, itself derived from the conjugate addition of O, N-dibenzylhydroxylamine to a highly activated α,β-unsaturated bicyclic lactam, provides direct access to conformationally constrained diamines. Sequential deprotection allows the synthesis of 3,4-diaminopyroglutaminols.

Original languageEnglish
Pages (from-to)3007-3012
Number of pages6
JournalJournal of the Chemical Society. Perkin Transactions 1
Volume1
Issue number22
DOIs
Publication statusPublished - 25 Oct 2001
Externally publishedYes

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