The electrophilic amination of a Ε γ-aminolactam, itself derived from the conjugate addition of O, N-dibenzylhydroxylamine to a highly activated α,β-unsaturated bicyclic lactam, provides direct access to conformationally constrained diamines. Sequential deprotection allows the synthesis of 3,4-diaminopyroglutaminols.
|Number of pages||6|
|Journal||Journal of the Chemical Society. Perkin Transactions 1|
|Publication status||Published - 25 Oct 2001|