Pyrrolidinones derived from (S)-pyroglutamic acid. Part 4. α, β-Diaminopyrrolidinones

Philip W.H. Chan; Ian F. Cottrell; Mark G. Moloney

doi:10.1039/b106783b

Pyrrolidinones derived from (S)-pyroglutamic acid. Part 4. α, β-Diaminopyrrolidinones

Philip W.H. Chan, Ian F. Cottrell, Mark G. Moloney

Research output: Contribution to journal › Article › Research › peer-review

17 Citations (Scopus)

Abstract

The electrophilic amination of a Ε γ-aminolactam, itself derived from the conjugate addition of O, N-dibenzylhydroxylamine to a highly activated α,β-unsaturated bicyclic lactam, provides direct access to conformationally constrained diamines. Sequential deprotection allows the synthesis of 3,4-diaminopyroglutaminols.

Original language	English
Pages (from-to)	3007-3012
Number of pages	6
Journal	Journal of the Chemical Society, Perkin Transactions 1
Volume	1
Issue number	22
DOIs	https://doi.org/10.1039/b106783b
Publication status	Published - 25 Oct 2001
Externally published	Yes

Access to Document

10.1039/b106783b

Cite this

@article{e72fd129dd124758a286f7c6261a3ae4,

title = "Pyrrolidinones derived from (S)-pyroglutamic acid. Part 4. α, β-Diaminopyrrolidinones",

abstract = "The electrophilic amination of a Ε γ-aminolactam, itself derived from the conjugate addition of O, N-dibenzylhydroxylamine to a highly activated α,β-unsaturated bicyclic lactam, provides direct access to conformationally constrained diamines. Sequential deprotection allows the synthesis of 3,4-diaminopyroglutaminols.",

author = "Chan, {Philip W.H.} and Cottrell, {Ian F.} and Moloney, {Mark G.}",

year = "2001",

month = oct,

day = "25",

doi = "10.1039/b106783b",

language = "English",

volume = "1",

pages = "3007--3012",

journal = "Journal of the Chemical Society, Perkin Transactions 1",

issn = "1472-7781",

publisher = "The Royal Society of Chemistry",

number = "22",

}

TY - JOUR

T1 - Pyrrolidinones derived from (S)-pyroglutamic acid. Part 4. α, β-Diaminopyrrolidinones

AU - Chan, Philip W.H.

AU - Cottrell, Ian F.

AU - Moloney, Mark G.

PY - 2001/10/25

Y1 - 2001/10/25

N2 - The electrophilic amination of a Ε γ-aminolactam, itself derived from the conjugate addition of O, N-dibenzylhydroxylamine to a highly activated α,β-unsaturated bicyclic lactam, provides direct access to conformationally constrained diamines. Sequential deprotection allows the synthesis of 3,4-diaminopyroglutaminols.

AB - The electrophilic amination of a Ε γ-aminolactam, itself derived from the conjugate addition of O, N-dibenzylhydroxylamine to a highly activated α,β-unsaturated bicyclic lactam, provides direct access to conformationally constrained diamines. Sequential deprotection allows the synthesis of 3,4-diaminopyroglutaminols.

UR - http://www.scopus.com/inward/record.url?scp=0034746879&partnerID=8YFLogxK

U2 - 10.1039/b106783b

DO - 10.1039/b106783b

M3 - Article

AN - SCOPUS:0034746879

VL - 1

SP - 3007

EP - 3012

JO - Journal of the Chemical Society, Perkin Transactions 1

JF - Journal of the Chemical Society, Perkin Transactions 1

SN - 1472-7781

IS - 22

ER -

Pyrrolidinones derived from (S)-pyroglutamic acid. Part 4. α, β-Diaminopyrrolidinones

Abstract

Access to Document

Other files and links

Cite this