Abstract
The conjugate addition of activated nitrogen nucleophiles, such as hydroxylamine and hydrazine derivatives, to Ε β,β-unsaturated bicyclic lactam 1a gave the corresponding β-amino products 9a–g in good yield and excellent diastereoselectivity. These products can be manipulated to afford enantiopure β-aminopyrrolidinones of potential application as conformationally-constrained, substituted glutamate templates of well-defined stereochemistry.
Original language | English |
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Pages (from-to) | 2997-3006 |
Number of pages | 10 |
Journal | Journal of the Chemical Society. Perkin Transactions 1 |
Volume | 1 |
Issue number | 22 |
DOIs | |
Publication status | Published - 25 Oct 2001 |
Externally published | Yes |