Pyrazole NNRTIs 3: Optimisation of physicochemical properties

Charles E. Mowbray, Romuald Corbau, Michael Hawes, Lyn H. Jones, James E. Mills, Manos Perros, Matthew D. Selby, Paul A. Stupple, Rob Webster, Anthony Wood

Research output: Contribution to journalArticleResearchpeer-review

23 Citations (Scopus)

Abstract

Our efforts to reduce overall lipophilicity and increase ligand-lipophilicity efficiency (LLE) by modification of the 3- and 5-substituents of pyrazole 1, a novel non-nucleoside HIV reverse transcriptase inhibitor (NNRTI) prototype were unsuccessful. In contrast replacement of the substituted benzyl group with corresponding phenylthio or phenoxy groups resulted in marked improvements in potency, ligand efficiency (LE) and LLE.

Original languageEnglish
Pages (from-to)5603-5606
Number of pages4
JournalBioorganic and Medicinal Chemistry Letters
Volume19
Issue number19
DOIs
Publication statusPublished - 1 Oct 2009
Externally publishedYes

Keywords

  • HIV
  • NNRTI
  • Reverse transcriptase

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