Pyrazole NNRTIs 3: Optimisation of physicochemical properties

Charles E. Mowbray, Romuald Corbau, Michael Hawes, Lyn H. Jones, James E. Mills, Manos Perros, Matthew D. Selby, Paul A. Stupple, Rob Webster, Anthony Wood

Research output: Contribution to journalArticleResearchpeer-review

25 Citations (Scopus)


Our efforts to reduce overall lipophilicity and increase ligand-lipophilicity efficiency (LLE) by modification of the 3- and 5-substituents of pyrazole 1, a novel non-nucleoside HIV reverse transcriptase inhibitor (NNRTI) prototype were unsuccessful. In contrast replacement of the substituted benzyl group with corresponding phenylthio or phenoxy groups resulted in marked improvements in potency, ligand efficiency (LE) and LLE.

Original languageEnglish
Pages (from-to)5603-5606
Number of pages4
JournalBioorganic and Medicinal Chemistry Letters
Issue number19
Publication statusPublished - 1 Oct 2009
Externally publishedYes


  • HIV
  • Reverse transcriptase

Cite this