Pyrazole NNRTIs 1: Design and initial optimisation of a novel template

Charles E. Mowbray; Catherine Burt; Romuald Corbau; Manos Perros; Isabelle Tran; Paul A. Stupple; Rob Webster; Anthony Wood

doi:10.1016/j.bmcl.2009.08.039

Pyrazole NNRTIs 1: Design and initial optimisation of a novel template

Charles E. Mowbray
, Catherine Burt
, Romuald Corbau
, Manos Perros
, Isabelle Tran
, Paul A. Stupple
, Rob Webster
, Anthony Wood

Research output: Contribution to journal › Article › Research › peer-review

38 Citations (Scopus)

Abstract

The design and synthesis of a novel series of non-nucleoside HIV reverse transcriptase inhibitors (NNRTIs) based on a pyrazole template is described. These compounds are active against wild type reverse transcriptase (RT) and retain activity against clinically important mutants.

Original language	English
Pages (from-to)	5599-5602
Number of pages	4
Journal	Bioorganic and Medicinal Chemistry Letters
Volume	19
Issue number	19
DOIs	https://doi.org/10.1016/j.bmcl.2009.08.039
Publication status	Published - 1 Oct 2009
Externally published	Yes

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

HIV
NNRTI
Reverse transcriptase

Access to Document

10.1016/j.bmcl.2009.08.039

Cite this

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title = "Pyrazole NNRTIs 1: Design and initial optimisation of a novel template",

abstract = "The design and synthesis of a novel series of non-nucleoside HIV reverse transcriptase inhibitors (NNRTIs) based on a pyrazole template is described. These compounds are active against wild type reverse transcriptase (RT) and retain activity against clinically important mutants.",

keywords = "HIV, NNRTI, Reverse transcriptase",

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doi = "10.1016/j.bmcl.2009.08.039",

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T2 - Design and initial optimisation of a novel template

AU - Mowbray, Charles E.

AU - Burt, Catherine

AU - Corbau, Romuald

AU - Perros, Manos

AU - Tran, Isabelle

AU - Stupple, Paul A.

AU - Webster, Rob

AU - Wood, Anthony

PY - 2009/10/1

Y1 - 2009/10/1

N2 - The design and synthesis of a novel series of non-nucleoside HIV reverse transcriptase inhibitors (NNRTIs) based on a pyrazole template is described. These compounds are active against wild type reverse transcriptase (RT) and retain activity against clinically important mutants.

AB - The design and synthesis of a novel series of non-nucleoside HIV reverse transcriptase inhibitors (NNRTIs) based on a pyrazole template is described. These compounds are active against wild type reverse transcriptase (RT) and retain activity against clinically important mutants.

KW - HIV

KW - NNRTI

KW - Reverse transcriptase

UR - https://www.scopus.com/pages/publications/69949092805

U2 - 10.1016/j.bmcl.2009.08.039

DO - 10.1016/j.bmcl.2009.08.039

M3 - Article

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AN - SCOPUS:69949092805

SN - 0960-894X

VL - 19

SP - 5599

EP - 5602

JO - Bioorganic and Medicinal Chemistry Letters

JF - Bioorganic and Medicinal Chemistry Letters

IS - 19

ER -

Pyrazole NNRTIs 1: Design and initial optimisation of a novel template

Abstract

UN SDGs

Keywords

Access to Document

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