Pyrazole NNRTIs 1: Design and initial optimisation of a novel template

Charles E. Mowbray, Catherine Burt, Romuald Corbau, Manos Perros, Isabelle Tran, Paul A. Stupple, Rob Webster, Anthony Wood

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25 Citations (Scopus)

Abstract

The design and synthesis of a novel series of non-nucleoside HIV reverse transcriptase inhibitors (NNRTIs) based on a pyrazole template is described. These compounds are active against wild type reverse transcriptase (RT) and retain activity against clinically important mutants.

Original languageEnglish
Pages (from-to)5599-5602
Number of pages4
JournalBioorganic and Medicinal Chemistry Letters
Volume19
Issue number19
DOIs
Publication statusPublished - 1 Oct 2009
Externally publishedYes

Keywords

  • HIV
  • NNRTI
  • Reverse transcriptase

Cite this

Mowbray, C. E., Burt, C., Corbau, R., Perros, M., Tran, I., Stupple, P. A., Webster, R., & Wood, A. (2009). Pyrazole NNRTIs 1: Design and initial optimisation of a novel template. Bioorganic and Medicinal Chemistry Letters, 19(19), 5599-5602. https://doi.org/10.1016/j.bmcl.2009.08.039