TY - JOUR
T1 - Pyoderma gangrenosum requiring inpatient management
T2 - A report of 26 cases with follow up
AU - Saracino, Amanda
AU - Kelly, Rob
AU - Liew, Danny
AU - Chong, Alvin Heong
PY - 2011/8
Y1 - 2011/8
N2 - We present a case series of inpatients with pyoderma gangrenosum (PG), an ulcerative neutrophilic skin condition of unknown aetiology. Twenty-six patients were admitted with PG, nine men and 17 women. At the time of the chart review, seven patients (26.9%) had died. Patients had a mean of 2.0 active ulcerative lesions and 22 patients' ulcers (84.6%) were on the lower limb. Systemic diseases were coexistent in 15 patients (57.7%), the most common being rheumatoid arthritis (19.2%). Thirty-eight wound cultures were taken and were positive for Staphylococcus aureus in 22 cases (57.8%) and Pseudomonas aeruginosa in 20 (52.6%). After prednisolone, cyclosporin was the next most commonly prescribed systemic therapy (34.6%). Surgical debridement was undertaken in seven cases (26.9%) and two patients had skin grafts. Upon discharge from hospital, 21 patients' ulcers (80.8%) had improved. At 6 months 50% showed complete ulcer healing. Our results highlight the potential severity of PG requiring hospital admission, the need for aggressive therapy and the overall high associated morbidity and mortality.
AB - We present a case series of inpatients with pyoderma gangrenosum (PG), an ulcerative neutrophilic skin condition of unknown aetiology. Twenty-six patients were admitted with PG, nine men and 17 women. At the time of the chart review, seven patients (26.9%) had died. Patients had a mean of 2.0 active ulcerative lesions and 22 patients' ulcers (84.6%) were on the lower limb. Systemic diseases were coexistent in 15 patients (57.7%), the most common being rheumatoid arthritis (19.2%). Thirty-eight wound cultures were taken and were positive for Staphylococcus aureus in 22 cases (57.8%) and Pseudomonas aeruginosa in 20 (52.6%). After prednisolone, cyclosporin was the next most commonly prescribed systemic therapy (34.6%). Surgical debridement was undertaken in seven cases (26.9%) and two patients had skin grafts. Upon discharge from hospital, 21 patients' ulcers (80.8%) had improved. At 6 months 50% showed complete ulcer healing. Our results highlight the potential severity of PG requiring hospital admission, the need for aggressive therapy and the overall high associated morbidity and mortality.
KW - leg ulcers
KW - neutrophilic dermatosis
KW - pyoderma gangrenosum
UR - http://www.scopus.com/inward/record.url?scp=80051793547&partnerID=8YFLogxK
U2 - 10.1111/j.1440-0960.2011.00750.x
DO - 10.1111/j.1440-0960.2011.00750.x
M3 - Article
C2 - 21834821
AN - SCOPUS:80051793547
SN - 0004-8380
VL - 52
SP - 218
EP - 221
JO - Australasian Journal of Dermatology
JF - Australasian Journal of Dermatology
IS - 3
ER -