Pulmonary Hypertension in an Infant Treated with Ibuprofen

Presence of symptomatic patent ductus arteriosus is common in small preterm infants and ibuprofen is commonly used for its medical closure. While efficacy is comparable to indomethacin, there are a few case reports of severe hypoxemia and pulmonary hypertension following prophylactic ibuprofen administration. Possible mechanisms of occurrence of this complication in a preterm infant are discussed.