Pulmonary and systemic pharmacokinetics of inhaled and intravenous colistin methanesulfonate in cystic fibrosis patients: Targeting advantage of inhalational administration

Shalini Wickramaratne Senarath Yapa, Jian Li, Kashyap Patel, John W Wilson, Michael Joseph Dooley, Johnson George, Denise Clark, Susan Gaye Poole, Elyssa Williams, Christopher John Porter, Roger Leigh Nation, Michelle Paula McIntosh

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Abstract

The purpose of this study was to define the pulmonary and systemic pharmacokinetics of colistin methanesulfonate (CMS) and formed colistin following intravenous (i.v.) and inhaled administration in cystic fibrosis (CF) patients. Six CF subjects were administered nebulized CMS doses of 2 and 4 million IU and an i.v. CMS infusion of 150 mg of colistin base activity. Blood plasma, sputum, and urine samples were collected for 12 to 24 h postdose. To assess the tolerability of the drug, lung function tests, blood serum creatinine concentrations, and adverse effect reports were recorded. All doses were well tolerated in the subjects. The pharmacokinetic parameters for CMS following i.v. delivery were consistent with previously reported values. Sputum concentrations of formed colistin were maintained at
Original languageEnglish
Pages (from-to)2570 - 2579
Number of pages10
JournalAntimicrobial Agents and Chemotherapy
Volume58
Issue number5
DOIs
Publication statusPublished - 2014

Cite this

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title = "Pulmonary and systemic pharmacokinetics of inhaled and intravenous colistin methanesulfonate in cystic fibrosis patients: Targeting advantage of inhalational administration",
abstract = "The purpose of this study was to define the pulmonary and systemic pharmacokinetics of colistin methanesulfonate (CMS) and formed colistin following intravenous (i.v.) and inhaled administration in cystic fibrosis (CF) patients. Six CF subjects were administered nebulized CMS doses of 2 and 4 million IU and an i.v. CMS infusion of 150 mg of colistin base activity. Blood plasma, sputum, and urine samples were collected for 12 to 24 h postdose. To assess the tolerability of the drug, lung function tests, blood serum creatinine concentrations, and adverse effect reports were recorded. All doses were well tolerated in the subjects. The pharmacokinetic parameters for CMS following i.v. delivery were consistent with previously reported values. Sputum concentrations of formed colistin were maintained at",
author = "{Wickramaratne Senarath Yapa}, Shalini and Jian Li and Kashyap Patel and Wilson, {John W} and Dooley, {Michael Joseph} and Johnson George and Denise Clark and Poole, {Susan Gaye} and Elyssa Williams and Porter, {Christopher John} and Nation, {Roger Leigh} and McIntosh, {Michelle Paula}",
year = "2014",
doi = "10.1128/AAC.01705-13",
language = "English",
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pages = "2570 -- 2579",
journal = "Antimicrobial Agents and Chemotherapy",
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TY - JOUR

T1 - Pulmonary and systemic pharmacokinetics of inhaled and intravenous colistin methanesulfonate in cystic fibrosis patients: Targeting advantage of inhalational administration

AU - Wickramaratne Senarath Yapa, Shalini

AU - Li, Jian

AU - Patel, Kashyap

AU - Wilson, John W

AU - Dooley, Michael Joseph

AU - George, Johnson

AU - Clark, Denise

AU - Poole, Susan Gaye

AU - Williams, Elyssa

AU - Porter, Christopher John

AU - Nation, Roger Leigh

AU - McIntosh, Michelle Paula

PY - 2014

Y1 - 2014

N2 - The purpose of this study was to define the pulmonary and systemic pharmacokinetics of colistin methanesulfonate (CMS) and formed colistin following intravenous (i.v.) and inhaled administration in cystic fibrosis (CF) patients. Six CF subjects were administered nebulized CMS doses of 2 and 4 million IU and an i.v. CMS infusion of 150 mg of colistin base activity. Blood plasma, sputum, and urine samples were collected for 12 to 24 h postdose. To assess the tolerability of the drug, lung function tests, blood serum creatinine concentrations, and adverse effect reports were recorded. All doses were well tolerated in the subjects. The pharmacokinetic parameters for CMS following i.v. delivery were consistent with previously reported values. Sputum concentrations of formed colistin were maintained at

AB - The purpose of this study was to define the pulmonary and systemic pharmacokinetics of colistin methanesulfonate (CMS) and formed colistin following intravenous (i.v.) and inhaled administration in cystic fibrosis (CF) patients. Six CF subjects were administered nebulized CMS doses of 2 and 4 million IU and an i.v. CMS infusion of 150 mg of colistin base activity. Blood plasma, sputum, and urine samples were collected for 12 to 24 h postdose. To assess the tolerability of the drug, lung function tests, blood serum creatinine concentrations, and adverse effect reports were recorded. All doses were well tolerated in the subjects. The pharmacokinetic parameters for CMS following i.v. delivery were consistent with previously reported values. Sputum concentrations of formed colistin were maintained at

UR - http://aac.asm.org/content/58/5/2570.full.pdf+html

U2 - 10.1128/AAC.01705-13

DO - 10.1128/AAC.01705-13

M3 - Article

VL - 58

SP - 2570

EP - 2579

JO - Antimicrobial Agents and Chemotherapy

JF - Antimicrobial Agents and Chemotherapy

SN - 1098-6596

IS - 5

ER -