Pulling RANK: Are some melanoma cells more malignant than others

Mark Shackleton

Research output: Contribution to journalComment / DebateOtherpeer-review


Cellular heterogeneity is a frequently noted feature of melanoma. As reported in this issue, Kupas et al. identified heterogeneous expression of receptor activator of nuclear factor-B (RANK) in melanoma cells in tumors and peripheral blood from patients. Increased expression of RANK was associated with the presence of metastatic disease and increased tumorigenicity in melanoma cells, raising the possibility that RANK signaling contributes to melanoma progression.

Original languageEnglish
Pages (from-to)814-816
Number of pages3
JournalJournal of Investigative Dermatology
Issue number4
Publication statusPublished - 1 Jan 2011
Externally publishedYes

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