This article reviews research on the effectiveness of four categories of intervention when implemented in public schools with adolescents and young adults diagnosed with an autism spectrum disorder. The study s inclusionary criteria include a setting of public schools, participants aged between 12 and 22 years, and the investigation of an antecedent-, consequence-, self-management-, or video-based intervention strategy to influence skills or behaviors in students. A total of 34 studies met these criteria. The procedures of the What Works Clearinghouse Standards for Single-Case Designs and Evidence are used to evaluate whether sufficient high-quality research in using antecedent-, consequence-, self-management-, and video-based strategies exists to consider these evidence-based practices. Intervention effectiveness is estimated using PAND scores and phi coefficients. The results suggest that sufficient research exists to consider antecedent-, video-, and consequence-based interventions evidence-based practices for adolescents and young adults in public schools. The need for more applied research with adolescents and young adults is highlighted.