PTPN22 is associated with susceptibility to psoriatic arthritis but not psoriasis: evidence for a further PsA-specific risk locus

John Bowes, Sabine Loehr, Ashley Budu-Aggrey, Steffen Uebe, Ian N Bruce, Marie Feletar, Helena Marzo-Ortega, Philip Helliwell, Anthony Ryan, David John Kane, Eleanor Korendowych, Gerd-Marie Alenius, Emiliano Giardina, Jonathan Packham, Ross McManus, Oliver Fitzgerald, Matthew Arthur Brown, Frank Behrens, Harald Burkhardt, Neil McHughUlrike Huffmeier, Pauline Ho, Andreas Reis, Anne Barton

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Abstract

Annals of the Rheumatic Diseases Volume 74, Issue 10, 1 October 2015, Pages 1882-1885 PTPN22 is associated with susceptibility to psoriatic arthritis but not psoriasis: Evidence for a further PSA-specific risk locus (Article) Bowes, J.a, Loehr, S.b, Budu-Aggrey, A.ac, Uebe, S.b, Bruce, I.N.acd, Feletar, M.e, Marzo-Ortega, H.f, Helliwell, P.f, Ryan, A.W.g, Kane, D.h, Korendowych, E.i, Alenius, G.-M.j, Giardina, E.k, Packham, J.l, McManus, R.g, Fitzgerald, O.m, Brown, M.A.n, Behrens, F.o, Burkhardt, H.o, McHugh, N.i, Huffmeier, U.b, Ho, P.ad, Reis, A.b, Barton, A.acd a Arthritis Research UK Centre for Epidemiology, Centre for Musculoskeletal Research, Institute for Inflammation and Repair, Manchester Academic Health Science Centre, University of Manchester, Manchester, United Kingdom b Institute of Human Genetics, University of Erlangen-Nuremberg, Erlangen, Germany c NIHR Manchester Musculoskeletal Biomedical Research Unit, Central Manchester University Hospitals NHS Foundation Trust, Manchester Academic Health Science Centre, Manchester, United Kingdom View additional affiliations View references (22) Abstract Objectives: Psoriatic arthritis (PsA) is a chronic inflammatory arthritis associated with psoriasis; it has a higher estimated genetic component than psoriasis alone, however most genetic susceptibility loci identified for PsA to date are also shared with psoriasis. Here we attempt to validate novel single nucleotide polymorphisms selected from our recent PsA Immunochip study and determine specificity to PsA. Methods: A total of 15 single nucleotide polymorphisms were selected (PImmunochip
Original languageEnglish
Pages (from-to)1882 - 1885
Number of pages4
JournalAnnals of the Rheumatic Diseases
Volume74
Issue number10
DOIs
Publication statusPublished - 2015

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