PTPN22 is associated with susceptibility to psoriatic arthritis but not psoriasis: evidence for a further PsA-specific risk locus

Annals of the Rheumatic Diseases Volume 74, Issue 10, 1 October 2015, Pages 1882-1885 PTPN22 is associated with susceptibility to psoriatic arthritis but not psoriasis: Evidence for a further PSA-specific risk locus (Article) Bowes, J.a, Loehr, S.b, Budu-Aggrey, A.ac, Uebe, S.b, Bruce, I.N.acd, Feletar, M.e, Marzo-Ortega, H.f, Helliwell, P.f, Ryan, A.W.g, Kane, D.h, Korendowych, E.i, Alenius, G.-M.j, Giardina, E.k, Packham, J.l, McManus, R.g, Fitzgerald, O.m, Brown, M.A.n, Behrens, F.o, Burkhardt, H.o, McHugh, N.i, Huffmeier, U.b, Ho, P.ad, Reis, A.b, Barton, A.acd a Arthritis Research UK Centre for Epidemiology, Centre for Musculoskeletal Research, Institute for Inflammation and Repair, Manchester Academic Health Science Centre, University of Manchester, Manchester, United Kingdom b Institute of Human Genetics, University of Erlangen-Nuremberg, Erlangen, Germany c NIHR Manchester Musculoskeletal Biomedical Research Unit, Central Manchester University Hospitals NHS Foundation Trust, Manchester Academic Health Science Centre, Manchester, United Kingdom View additional affiliations View references (22) Abstract Objectives: Psoriatic arthritis (PsA) is a chronic inflammatory arthritis associated with psoriasis; it has a higher estimated genetic component than psoriasis alone, however most genetic susceptibility loci identified for PsA to date are also shared with psoriasis. Here we attempt to validate novel single nucleotide polymorphisms selected from our recent PsA Immunochip study and determine specificity to PsA. Methods: A total of 15 single nucleotide polymorphisms were selected (PImmunochip