Projects per year
Abstract
In the thymus, hematopoietic progenitors commit to the T cell lineage and undergo sequential differentiation to generate diverse T cell subsets, including major histocompatibility complex (MHC)-restricted αß T cell receptor (TCR ) T cells and non- MHC-restricted γδ TCR T cells. The factors controlling precursor commitment and their subsequent maturation and specification into αß TCR versus γδ TCR T cells remain unclear. Here, we show that the tyrosine phosphatase PTPN2 attenuates STAT5 (signal transducer and activator of transcription 5) signaling to regulate T cell lineage commitment and SRC family kinase LCK and STAT5 signaling to regulate αß TCR versus γδ TCR T cell development. Our findings identify PTPN2 as an important regulator of critical checkpoints that dictate the commitment of multipotent precursors to the T cell lineage and their subsequent maturation into αß TCR or γδ TCR T cells.
Original language | English |
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Pages (from-to) | 2733-2758 |
Number of pages | 26 |
Journal | Journal of Experimental Medicine |
Volume | 214 |
Issue number | 9 |
DOIs | |
Publication status | Published - 4 Sept 2017 |
Projects
- 5 Finished
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PTPN2 and adoptive T cell immunotherapy
Wiede, F. (Primary Chief Investigator (PCI))
1/01/16 → 31/12/18
Project: Research
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ARC Centre of Excellence in Advanced Molecular Imaging
Whisstock, J. (Primary Chief Investigator (PCI)), Abbey, B. (Chief Investigator (CI)), Nugent, K. A. (Chief Investigator (CI)), Quiney, H. M. (Chief Investigator (CI)), Godfrey, D. I. (Chief Investigator (CI)), Heath, W. (Chief Investigator (CI)), Fairlie, D. P. (Chief Investigator (CI)), Chapman, H. (Partner Investigator (PI)), Peele, A. (Partner Investigator (PI)), Davey, J. (Partner Investigator (PI)) & Wittmann, A. (Project Manager)
30/06/14 → 31/03/21
Project: Research
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The role of the T cell protein tyrosine phosphatase in autoimmunity
Tiganis, T. (Primary Chief Investigator (PCI))
NHMRC - National Health and Medical Research Council (Australia)
1/01/13 → 31/12/15
Project: Research