PTPN2 Deficiency Enhances Programmed T Cell Expansion and Survival Capacity of Activated T Cells

Markus Flosbach, Susanne G. Oberle, Stefanie Scherer, Jana Zecha, Madlaina von Hoesslin, Florian Wiede, Vijaykumar Chennupati, Jolie G. Cullen, Markus List, Josch K. Pauling, Jan Baumbach, Bernhard Kuster, Tony Tiganis, Dietmar Zehn

Research output: Contribution to journalArticleResearchpeer-review

2 Citations (Scopus)

Abstract

Manipulating PTPN2 has potential for advancing immunotherapies. However, it is unclear how PTPN2 impacts the activation, survival, and memory formation of T cells. Flosbach et al. demonstrate that PTPN2-deficient T cells are less dependent on cytokines and show increased programmed expansion, and short-lived effector T cells have enhanced survival and expansion capacity.

Original languageEnglish
Article number107957
Number of pages16
JournalCell Reports
Volume32
Issue number4
DOIs
Publication statusPublished - 28 Jul 2020

Keywords

  • adoptive T cell transfer
  • autoimmunity
  • effector T cells
  • GWAS
  • immunotherapy
  • phosphoproteome
  • programmed T cell expansion
  • Protein tyrosine phosphatase non‑receptor type 2 (PTPN2)
  • single point mutation
  • T cell memory

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