PTHrP, its receptor, and protein kinase A activation in osteosarcoma

Carl R. Walkley; Mannu K. Walia; Patricia W. Ho; T. John Martin

doi:10.4161/23723548.2014.965624

PTHrP, its receptor, and protein kinase A activation in osteosarcoma

Carl R. Walkley, Mannu K. Walia, Patricia W. Ho, T. John Martin

Research output: Contribution to journal › Article › Research › peer-review

18 Citations (Scopus)

Abstract

In osteosarcoma, knockdown of the parathyroid hormone-related protein (PTHrP) receptor reduces activation through cyclic AMP-dependent protein kinase A (PKA) and substantially decreases tumor differentiation, invasion, and proliferation in vivo. These findings complement other evidence supporting a central role of the PKA pathway in osteosarcoma biology and pathogenesis.

Original language	English
Article number	e965624
Number of pages	3
Journal	Molecular and Cellular Oncology
Volume	1
Issue number	4
DOIs	https://doi.org/10.4161/23723548.2014.965624
Publication status	Published - 8 Dec 2014
Externally published	Yes

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

osteosarcoma
PKA
PTHR1
PTHrP

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10.4161/23723548.2014.965624

Cite this

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title = "PTHrP, its receptor, and protein kinase A activation in osteosarcoma",

abstract = "In osteosarcoma, knockdown of the parathyroid hormone-related protein (PTHrP) receptor reduces activation through cyclic AMP-dependent protein kinase A (PKA) and substantially decreases tumor differentiation, invasion, and proliferation in vivo. These findings complement other evidence supporting a central role of the PKA pathway in osteosarcoma biology and pathogenesis.",

keywords = "osteosarcoma, PKA, PTHR1, PTHrP",

author = "Walkley, \{Carl R.\} and Walia, \{Mannu K.\} and Ho, \{Patricia W.\} and Martin, \{T. John\}",

note = "Funding Information: Work from the authors{\textquoteright} laboratories is supported by the NHMRC (Australia), Cancer Council of Victoria, Zig Inge Foundation, 5 Point Foundation, and by the Victorian State Government Opera tional Infrastructure Support Program (to St. Vincent{\textquoteright}s Institute). C.W. is the Philip Desbrow Senior Research Fellow of the Leukaemia Foundation. Publisher Copyright: {\textcopyright} 2014, {\textcopyright} 2014 The Author(s). Published with license by Taylor \& Francis Group, LLC. {\textcopyright} 2014, {\textcopyright} Carl R Walkley, Mannu K Walia, Patricia W M Ho, and T John Martin.",

year = "2014",

month = dec,

day = "8",

doi = "10.4161/23723548.2014.965624",

language = "English",

volume = "1",

journal = "Molecular and Cellular Oncology",

issn = "2372-3556",

publisher = "Taylor \& Francis",

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T1 - PTHrP, its receptor, and protein kinase A activation in osteosarcoma

AU - Walkley, Carl R.

AU - Walia, Mannu K.

AU - Ho, Patricia W.

AU - Martin, T. John

N1 - Funding Information: Work from the authors’ laboratories is supported by the NHMRC (Australia), Cancer Council of Victoria, Zig Inge Foundation, 5 Point Foundation, and by the Victorian State Government Opera tional Infrastructure Support Program (to St. Vincent’s Institute). C.W. is the Philip Desbrow Senior Research Fellow of the Leukaemia Foundation. Publisher Copyright: © 2014, © 2014 The Author(s). Published with license by Taylor & Francis Group, LLC. © 2014, © Carl R Walkley, Mannu K Walia, Patricia W M Ho, and T John Martin.

PY - 2014/12/8

Y1 - 2014/12/8

N2 - In osteosarcoma, knockdown of the parathyroid hormone-related protein (PTHrP) receptor reduces activation through cyclic AMP-dependent protein kinase A (PKA) and substantially decreases tumor differentiation, invasion, and proliferation in vivo. These findings complement other evidence supporting a central role of the PKA pathway in osteosarcoma biology and pathogenesis.

AB - In osteosarcoma, knockdown of the parathyroid hormone-related protein (PTHrP) receptor reduces activation through cyclic AMP-dependent protein kinase A (PKA) and substantially decreases tumor differentiation, invasion, and proliferation in vivo. These findings complement other evidence supporting a central role of the PKA pathway in osteosarcoma biology and pathogenesis.

KW - osteosarcoma

KW - PKA

KW - PTHR1

KW - PTHrP

UR - https://www.scopus.com/pages/publications/84928527021

U2 - 10.4161/23723548.2014.965624

DO - 10.4161/23723548.2014.965624

M3 - Article

AN - SCOPUS:84928527021

SN - 2372-3556

VL - 1

JO - Molecular and Cellular Oncology

JF - Molecular and Cellular Oncology

IS - 4

M1 - e965624

ER -

PTHrP, its receptor, and protein kinase A activation in osteosarcoma

Abstract

UN SDGs

Keywords

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