PTHrP, its receptor, and protein kinase A activation in osteosarcoma

Carl R. Walkley, Mannu K. Walia, Patricia W. Ho, T. John Martin

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15 Citations (Scopus)


In osteosarcoma, knockdown of the parathyroid hormone-related protein (PTHrP) receptor reduces activation through cyclic AMP-dependent protein kinase A (PKA) and substantially decreases tumor differentiation, invasion, and proliferation in vivo. These findings complement other evidence supporting a central role of the PKA pathway in osteosarcoma biology and pathogenesis.

Original languageEnglish
Article numbere965624
Number of pages3
JournalMolecular and Cellular Oncology
Issue number4
Publication statusPublished - 8 Dec 2014
Externally publishedYes


  • osteosarcoma
  • PKA
  • PTHR1
  • PTHrP

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