Psychotic disorder and focal epilepsy in a left-handed patient with chromosome XYY abnormality

Anna Pia Verri, C. A. Galimberti, P. Perucca, A. Cremante, M. Vernice, A. Uggetti

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4 Citations (Scopus)

Abstract

Psychotic disorder and focal epilepsy in a left-handed patient with chromosome XYY abnormality: Objective: To discuss the relationship between XYY chromosome abnormality, psychiatric disorders and epilepsy. Method: Single case report. Results: A 34-year-old man with 47, XYY karyotype and normal intelligence was followed-up at a neuropsychiatric clinic for over 30 years. He was first seen at age 3 years with a history of delayed motor and language development and an immunodeficiency syndrome. At age 8 years he developed refractory focal epilepsy, and in late adolescence he started to exhibit increasingly prominent obsessive thoughts, paranoid ideation, and aggressive sexual fantasies and behaviour. Conclusions: When interpreted within the context of previous literature reports, this case suggests a pathophysiological link between XYY chromosome abnormality, characteristic psychiatric symptoms and epilepsy disorder.

Original languageEnglish
Pages (from-to)373-379
Number of pages7
JournalGenetic Counseling
Volume19
Issue number4
Publication statusPublished - 2008
Externally publishedYes

Keywords

  • Case report
  • Epilepsy
  • Psychotic disorder
  • XYY chromosome disorder

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