TY - JOUR
T1 - Psychosocial therapies for the adjunctive treatment of bipolar disorder in adults
T2 - Network meta-analysis
AU - Chatterton, Mary Lou
AU - Stockings, Emily
AU - Berk, Michael
AU - Barendregt, Jan J.
AU - Carter, Rob
AU - Mihalopoulos, Cathrine
N1 - Funding Information:
This project was funded by the National Health and Medical Research Council (NHMRC grant APP1041131); E.S. and C.M. are supported by NHMRC Early Career Fellowships (1104600 and 1035887 respectively) and M.B. is supported by a NHMRC Senior Principal Research Fellowship 1059660. The views expressed in this paper are solely those of the authors and do not reflect the views of the NHMRC. The funder of the study had no role in study design, data collection, data analysis, data interpretation or writing of the report.
Publisher Copyright:
© The Royal College of Psychiatrists 2017.
PY - 2017/5
Y1 - 2017/5
N2 - Background Few trials have compared psychosocial therapies for people with bipolar affective disorder, and conventional metaanalyses provided limited comparisons between therapies. Aims To combine evidence for the efficacy of psychosocial interventions used as adjunctive treatment of bipolar disorder in adults, using network meta-analysis (NMA). Method Systematic review identified studies and NMA was used to pool data on relapse to mania or depression, medication adherence, and symptom scales for mania, depression and Global Assessment of Functioning (GAF). Results Carer-focused interventions significantly reduced the risk of depressive or manic relapse. Psychoeducation alone and in combination with cognitive-behavioural therapy (CBT) significantly reduced medication non-adherence. Psychoeducation plus CBT significantly reduced manic symptoms and increased GAF. No intervention was associated with a significant reduction in depression symptom scale scores. Conclusions Only interventions for family members affected relapse rates. Psychoeducation plus CBT reduced medication nonadherence, improved mania symptoms and GAF. Novel methods for addressing depressive symptoms are required.
AB - Background Few trials have compared psychosocial therapies for people with bipolar affective disorder, and conventional metaanalyses provided limited comparisons between therapies. Aims To combine evidence for the efficacy of psychosocial interventions used as adjunctive treatment of bipolar disorder in adults, using network meta-analysis (NMA). Method Systematic review identified studies and NMA was used to pool data on relapse to mania or depression, medication adherence, and symptom scales for mania, depression and Global Assessment of Functioning (GAF). Results Carer-focused interventions significantly reduced the risk of depressive or manic relapse. Psychoeducation alone and in combination with cognitive-behavioural therapy (CBT) significantly reduced medication non-adherence. Psychoeducation plus CBT significantly reduced manic symptoms and increased GAF. No intervention was associated with a significant reduction in depression symptom scale scores. Conclusions Only interventions for family members affected relapse rates. Psychoeducation plus CBT reduced medication nonadherence, improved mania symptoms and GAF. Novel methods for addressing depressive symptoms are required.
UR - http://www.scopus.com/inward/record.url?scp=85019932030&partnerID=8YFLogxK
U2 - 10.1192/bjp.bp.116.195321
DO - 10.1192/bjp.bp.116.195321
M3 - Review Article
C2 - 28209591
AN - SCOPUS:85019932030
SN - 0007-1250
VL - 210
SP - 333
EP - 341
JO - The British Journal of Psychiatry
JF - The British Journal of Psychiatry
IS - 5
ER -
