Psychosocial therapies for the adjunctive treatment of bipolar disorder in adults: Network meta-analysis

Mary Lou Chatterton, Emily Stockings, Michael Berk, Jan J. Barendregt, Rob Carter, Cathrine Mihalopoulos

Research output: Contribution to journalReview ArticleResearchpeer-review

48 Citations (Scopus)


Background Few trials have compared psychosocial therapies for people with bipolar affective disorder, and conventional metaanalyses provided limited comparisons between therapies. Aims To combine evidence for the efficacy of psychosocial interventions used as adjunctive treatment of bipolar disorder in adults, using network meta-analysis (NMA). Method Systematic review identified studies and NMA was used to pool data on relapse to mania or depression, medication adherence, and symptom scales for mania, depression and Global Assessment of Functioning (GAF). Results Carer-focused interventions significantly reduced the risk of depressive or manic relapse. Psychoeducation alone and in combination with cognitive-behavioural therapy (CBT) significantly reduced medication non-adherence. Psychoeducation plus CBT significantly reduced manic symptoms and increased GAF. No intervention was associated with a significant reduction in depression symptom scale scores. Conclusions Only interventions for family members affected relapse rates. Psychoeducation plus CBT reduced medication nonadherence, improved mania symptoms and GAF. Novel methods for addressing depressive symptoms are required.

Original languageEnglish
Pages (from-to)333-341
Number of pages9
JournalThe British Journal of Psychiatry
Issue number5
Publication statusPublished - May 2017
Externally publishedYes

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