Psychiatric history does not predict seizure outcome following temporal lobectomy for mesial temporal sclerosis

Sophia J. Adams, Dennis Velakoulis, Andrew H. Kaye, Niall M. Corcoran, Terence J. O'Brien

Research output: Contribution to journalArticleResearchpeer-review

20 Citations (Scopus)


Purpose: A lifetime psychiatric history has been reported to be associated with poorer seizure outcome following temporal lobectomy for drug-resistant focal epilepsy, but it remains unclear whether this is confounded by the nature of the epileptogenic pathology. Here we examined this association in a pathologically homogeneous group of patients with mesial temporal sclerosis (MTS). Methods: The study population included 72 consecutive patients who underwent a temporal lobectomy for drug resistant temporal lobe epilepsy (TLE) and had histopathologically proven MTS. All patients were assessed preoperatively by a neuropsychiatrist. Chi-square analysis was undertaken to look for demographic, clinical, psychiatric, or neurologic factors associated with seizure outcome at 1 year. The relationship between having a psychiatric disorder and seizure outcome was examined by generating Kaplan-Meier curves and comparing between groups the log rank test as well as generating Cox regression models to estimate hazard ratios. Key Findings: There were no significant associations between postsurgery seizure outcome and a current or lifetime history of any psychiatric disorder. Significance: A history of psychiatric disorder, in particular depression and psychosis, is not associated with a poorer surgical outcome in patients with MTS. These findings have implications for the clinical management of patients under consideration for temporal lobectomy.

Original languageEnglish
Pages (from-to)1700-1704
Number of pages5
Issue number10
Publication statusPublished - Oct 2012
Externally publishedYes


  • Mesial temporal lobe epilepsy
  • Psychiatric history
  • Temporal lobectomy

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