Psammomys obesus: a Natural Diet-Controlled Model for Diabetes and Cardiovascular Diseases

Rajneesh Chaudhary, Ken R. Walder, Christoph E. Hagemeyer, Jagat R. Kanwar

Research output: Contribution to journalReview ArticleResearchpeer-review

Abstract

Purpose of Review: This review specifically summarises and reports terrestrial mammals of the gerbil subfamily, known as Israeli sand rats or Psammomys obesus (P. obesus) as a diet-controlled, unique, polygenic rodent model for research in the areas of obesity, type 2 diabetes, and cardiovascular diseases. The animal model closely mimics phenotypic and pathophysiological resemblance with human populations. Recent Findings: The physiological status and biochemical composition in P. obesus can be manipulated effectively by controlling its nutritional intake, making it a natural model for cardiovascular and diabetic research. Humans exhibit remarkable disparity in physiology and pathology, which are inter-dependent factors. However, variations in these factors in most animal models currently being used for cardiovascular/diabetes research are insignificant. Consequently, it is a necessity to identify and develop animal models exhibiting physiological variations mimicking human pathological conditions. Summary: We have compiled research developments conducted with this rodent model manifesting pathophysiology, closely mimicking that in human beings, thereby enabling better translation of novel therapeutic and diagnostic discoveries.

Original languageEnglish
Article number46
Number of pages10
JournalCurrent Atherosclerosis Reports
Volume20
Issue number9
DOIs
Publication statusPublished - 1 Sep 2018

Keywords

  • Atherosclerosis
  • Cardiovascular diseases
  • Diabetes
  • Psammomys obesus
  • Sand rats

Cite this

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abstract = "Purpose of Review: This review specifically summarises and reports terrestrial mammals of the gerbil subfamily, known as Israeli sand rats or Psammomys obesus (P. obesus) as a diet-controlled, unique, polygenic rodent model for research in the areas of obesity, type 2 diabetes, and cardiovascular diseases. The animal model closely mimics phenotypic and pathophysiological resemblance with human populations. Recent Findings: The physiological status and biochemical composition in P. obesus can be manipulated effectively by controlling its nutritional intake, making it a natural model for cardiovascular and diabetic research. Humans exhibit remarkable disparity in physiology and pathology, which are inter-dependent factors. However, variations in these factors in most animal models currently being used for cardiovascular/diabetes research are insignificant. Consequently, it is a necessity to identify and develop animal models exhibiting physiological variations mimicking human pathological conditions. Summary: We have compiled research developments conducted with this rodent model manifesting pathophysiology, closely mimicking that in human beings, thereby enabling better translation of novel therapeutic and diagnostic discoveries.",
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Psammomys obesus : a Natural Diet-Controlled Model for Diabetes and Cardiovascular Diseases. / Chaudhary, Rajneesh; Walder, Ken R.; Hagemeyer, Christoph E.; Kanwar, Jagat R.

In: Current Atherosclerosis Reports, Vol. 20, No. 9, 46, 01.09.2018.

Research output: Contribution to journalReview ArticleResearchpeer-review

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