Protocols to study aging in Drosophila

Matthew D W Piper, Linda Partridge

Research output: Chapter in Book/Report/Conference proceedingChapter (Book)Otherpeer-review

9 Citations (Scopus)

Abstract

The fruit fly Drosophila melanogaster offers a host of advantages for studying the biology of aging: a wellunderstood biology, a wide range of genetic reagents, well-defined dietary requirements, and a relatively short life span, with a median of ~80 days and maximum ~100 days. Several phenotypes can be used to assess the aging process, but the simplest and most widely used metric is length of life. Here we describe a standard life span assay for Drosophila housed on a simple sugar/yeast diet.
Original languageEnglish
Title of host publicationDrosophila: Methods and Protocols
EditorsChristian Dahmann
Place of PublicationNew York NY USA
PublisherHumana Press
Pages291-302
Number of pages12
Edition2
ISBN (Electronic)9781493963713
ISBN (Print)978149396369
DOIs
Publication statusPublished - 12 Oct 2016

Publication series

NameMethods in Molecular Biology
PublisherHumana Press
Volume1478
ISSN (Print)1064-3745
ISSN (Electronic)1940-6029

Keywords

  • Aging
  • Backcross
  • Diet
  • Drosophila melanogaster
  • Genetic interventions
  • Life span
  • Method
  • Pharmacological interventions

Cite this

Piper, M. D. W., & Partridge, L. (2016). Protocols to study aging in Drosophila. In C. Dahmann (Ed.), Drosophila: Methods and Protocols (2 ed., pp. 291-302). (Methods in Molecular Biology; Vol. 1478). New York NY USA: Humana Press. https://doi.org/10.1007/978-1-4939-6371-3_18