Protocol of a study investigating breath-hold techniques for upper-abdominal radiation therapy (BURDIE): addressing the challenge of a moving target

Briana Farrugia, Richard Khor, Farshad Foroudi, Michael Chao, Kellie Knight, Caroline Wright

Research output: Contribution to journalArticleOtherpeer-review


Background: Radiation therapy to upper abdominal sites is technically challenging due to motion of tumors and surrounding organs resulting from normal respiration. Breath-hold, using an Active Breathing Coordinator is one strategy used to reduce motion in these tumor sites. Though widely used, no studies have prospectively compared the different breath-hold techniques (inspiration, deep-inspiration and expiration) using ABC in the same patient cohort. Methods: Patients planned for radiation therapy to upper abdominal tumors are invited to participate in this prospective study. Participants attempt three breath hold techniques: inspiration, deep-inspiration and expiration breath-hold, in random order. kV fluoroscopy images of the dome of diaphragm are taken of five consecutive breath-holds in each technique. Reproducibility and stability of tumour position are measured, and used to select the technique with which to proceed to planning and treatment. Reproducibility at planning and each treatment fraction is measured, along with breath hold time, treatment efficiency and patient experience. Discussion: The screening method was validated after the first three participants. This screening process may be able to select the best breath-hold technique for an individual, which may lead to improved reproducibility. The screening process is being piloted as a prospective clinical trial. Trial registration: Australian New Zealand Clinical Trials Registry (ANZCTR): 12618001691235. Registered 12th October 2018.

Original languageEnglish
Article number250
Number of pages7
JournalRadiation Oncology
Issue number1
Publication statusPublished - 2020


  • Breath holding
  • Neoplasms
  • Radiotherapy

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