Prothrombin complex concentrates used alone in urgent reversal of warfarin anticoagulation

H Tran, M Collecutt, S Whitehead, Hatem Hassan Salem

Research output: Contribution to journalArticleResearchpeer-review

38 Citations (Scopus)


Background: Prothrombinex-VF (a three-factor prothrombin complex concentrate) contains little factor VII. Therefore, the Warfarin Reversal Consensus Guidelines from 2004 published by The Australasian Society of Haemostasis and Thrombosis recommend that it be administered with fresh frozen plasma to reverse warfarin anticoagulation. Aim: To evaluate the efficacy and safety of Prothrombinex-VF used alone in warfarin reversal. Methods: Adult patients requiring urgent reversal of warfarin anticoagulation were defined as having achieved complete (target international normalized ratio (INR)
Original languageEnglish
Pages (from-to)337 - 343
Number of pages7
JournalInternal Medicine Journal
Issue number4
Publication statusPublished - 2011

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