Proteomics revisits the cancer metabolome

Hao Hu, Cao Deng, Tao Yang, Qiang Dong, Ya Chen, Edouard Nice, Canhua Huang, Yuquan Wei

Research output: Contribution to journalArticleResearchpeer-review

11 Citations (Scopus)

Abstract

Many cancer cells utilize aerobic glycolysis (also known as the Warburg effect ), instead of mitochondrial oxidative phosphorylation, to generate the energy necessary for diverse cellular processes. In tumor cells, mitochondria play more important roles in anabolism, for instance, de novo lipid biosynthesis and glutamine-dependent anaplerosis to fuel robust cell growth and proliferation. Proteomic analysis of tumor-related alterations of metabolism-associated proteins clearly indicates that such metabolic reprogramming contributes to cancer cell survival and cancer progression. Moreover, proteomics-based systems biology provides a powerful tool to re-evaluate the metabolic phenotype and regulatory mechanism associated with malignant cancer cells, and underscores their implications for cancer diagnosis and therapy. This article will address recent exciting advances in the understanding of cancer cell metabolism using proteomics-based systems biology approaches.
Original languageEnglish
Pages (from-to)505 - 533
Number of pages29
JournalExpert Review of Proteomics
Volume8
Issue number4
DOIs
Publication statusPublished - 2011

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