Proteoglycans: Potential Agents in Mammographic Density and the Associated Breast Cancer Risk

Michael S. Shawky; Carmela Ricciardelli; Megan Lord; John Whitelock; Vito Ferro; Kara Britt; Erik W. Thompson

doi:10.1007/s10911-015-9346-z

Proteoglycans: Potential Agents in Mammographic Density and the Associated Breast Cancer Risk

Michael S. Shawky, Carmela Ricciardelli, Megan Lord, John Whitelock, Vito Ferro, Kara Britt, Erik W. Thompson

Research output: Contribution to journal › Review Article › Research › peer-review

13 Citations (Scopus)

Abstract

Although increased mammographic density (MD) has been well established as a marker for increased breast cancer (BC) risk, its pathobiology is far from understood. Altered proteoglycan (PG) composition may underpin the physical properties of MD, and may contribute to the associated increase in BC risk. Numerous studies have investigated PGs, which are a major stromal matrix component, in relation to MD and BC and reported results that are sometimes discordant. Our review summarises these results and highlights discrepancies between PG associations with BC and MD, thus serving as a guide for identifying PGs that warrant further research towards developing chemo-preventive or therapeutic agents targeting pre-invasive or invasive breast lesions, respectively.

Original language	English
Pages (from-to)	121-131
Number of pages	11
Journal	Journal of Mammary Gland Biology and Neoplasia
Volume	20
Issue number	3-4
DOIs	https://doi.org/10.1007/s10911-015-9346-z
Publication status	Published - Dec 2015
Externally published	Yes

Keywords

Breast cancer
Extracellular matrix
Glypican
Heparanase
Mammographic density
Perlecan
Proteoglycans
Syndecan
Versican

Access to Document

10.1007/s10911-015-9346-z

Link to publication in Scopus

Cite this

@article{354087b96aae4d5c99c132c5add7d60f,

title = "Proteoglycans: Potential Agents in Mammographic Density and the Associated Breast Cancer Risk",

abstract = "Although increased mammographic density (MD) has been well established as a marker for increased breast cancer (BC) risk, its pathobiology is far from understood. Altered proteoglycan (PG) composition may underpin the physical properties of MD, and may contribute to the associated increase in BC risk. Numerous studies have investigated PGs, which are a major stromal matrix component, in relation to MD and BC and reported results that are sometimes discordant. Our review summarises these results and highlights discrepancies between PG associations with BC and MD, thus serving as a guide for identifying PGs that warrant further research towards developing chemo-preventive or therapeutic agents targeting pre-invasive or invasive breast lesions, respectively.",

keywords = "Breast cancer, Extracellular matrix, Glypican, Heparanase, Mammographic density, Perlecan, Proteoglycans, Syndecan, Versican",

author = "Shawky, {Michael S.} and Carmela Ricciardelli and Megan Lord and John Whitelock and Vito Ferro and Kara Britt and Thompson, {Erik W.}",

year = "2015",

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language = "English",

volume = "20",

pages = "121--131",

journal = "Journal of Mammary Gland Biology and Neoplasia",

issn = "1083-3021",

publisher = "Springer-Verlag London Ltd.",

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}

Proteoglycans : Potential Agents in Mammographic Density and the Associated Breast Cancer Risk. / Shawky, Michael S.; Ricciardelli, Carmela; Lord, Megan; Whitelock, John; Ferro, Vito; Britt, Kara; Thompson, Erik W.

In: Journal of Mammary Gland Biology and Neoplasia, Vol. 20, No. 3-4, 12.2015, p. 121-131.

Research output: Contribution to journal › Review Article › Research › peer-review

TY - JOUR

T1 - Proteoglycans

T2 - Potential Agents in Mammographic Density and the Associated Breast Cancer Risk

AU - Shawky, Michael S.

AU - Ricciardelli, Carmela

AU - Lord, Megan

AU - Whitelock, John

AU - Ferro, Vito

AU - Britt, Kara

AU - Thompson, Erik W.

PY - 2015/12

Y1 - 2015/12

N2 - Although increased mammographic density (MD) has been well established as a marker for increased breast cancer (BC) risk, its pathobiology is far from understood. Altered proteoglycan (PG) composition may underpin the physical properties of MD, and may contribute to the associated increase in BC risk. Numerous studies have investigated PGs, which are a major stromal matrix component, in relation to MD and BC and reported results that are sometimes discordant. Our review summarises these results and highlights discrepancies between PG associations with BC and MD, thus serving as a guide for identifying PGs that warrant further research towards developing chemo-preventive or therapeutic agents targeting pre-invasive or invasive breast lesions, respectively.

AB - Although increased mammographic density (MD) has been well established as a marker for increased breast cancer (BC) risk, its pathobiology is far from understood. Altered proteoglycan (PG) composition may underpin the physical properties of MD, and may contribute to the associated increase in BC risk. Numerous studies have investigated PGs, which are a major stromal matrix component, in relation to MD and BC and reported results that are sometimes discordant. Our review summarises these results and highlights discrepancies between PG associations with BC and MD, thus serving as a guide for identifying PGs that warrant further research towards developing chemo-preventive or therapeutic agents targeting pre-invasive or invasive breast lesions, respectively.

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KW - Extracellular matrix

KW - Glypican

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KW - Mammographic density

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KW - Syndecan

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JO - Journal of Mammary Gland Biology and Neoplasia

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