Protein-protein interactions in trans-AT polyketide synthases

Simone Kosol, Matthew Jenner, Józef R. Lewandowski, Gregory L. Challis

Research output: Contribution to journalReview ArticleResearchpeer-review

13 Citations (Scopus)


Covering: up to 2018 The construction of polyketide natural products by type I modular polyketide synthases (PKSs) requires the coordinated action of several protein subunits to ensure biosynthetic fidelity. This is particularly the case for trans-AT PKSs, which in contrast to most cis-AT PKSs, contain split modules and employ several trans-acting catalytic domains. This article summarises recent advances in understanding the protein-protein interactions underpinning subunit assembly and intra-subunit communication in such systems and highlights potential avenues and approaches for future research.

Original languageEnglish
Pages (from-to)1097-1109
Number of pages13
JournalNatural Product Reports
Issue number10
Publication statusPublished - 3 Oct 2018

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